Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study

Human Vaccines & Immunotherapeutics
Paul GillardArisa Okamasa

Abstract

Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. In this open-label, randomized, controlled, multicenter study, we evaluated the immunogenicity and safety of the DPT-IPV vaccine (Squarekids) administered concomitantly or staggered with the liquid HRV (Rotarix) vaccine in healthy Japanese infants. A total of 292 infants aged 6-12 weeks were randomly assigned to receive DPT-IPV vaccine and HRV vaccine co-administered (n = 147) or staggered (n = 145). Immune responses to DPT-IPV vaccine were evaluated by measuring the post-vaccination serum antibody titers/concentrations to each antigen at one month following the third dose of DPT-IPV vaccine. Seroprotection/seropositivity against each of the diphtheria, pertussis (pertussis toxin and filamentous hemagglutinin), tetanus, and poliovirus type 1, 2 and 3 a...Continue Reading

References

May 10, 2003·Emerging Infectious Diseases·Umesh D ParasharRoger I Glass
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
Feb 1, 2006·Vaccine·Manuel A FrancoHarry B Greenberg
Jan 29, 2010·The New England Journal of Medicine·Vesta RichardsonManish Patel
Feb 4, 2011·The Journal of Infectious Diseases·Ulrich Desselberger, Hans-Iko Huppertz
Aug 8, 2013·Journal of Medical Economics·Robbin ItzlerPraveen Dhankhar
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacqueline E TateUNKNOWN World Health Organization–Coordinated Global Rotavirus Surveillance Network

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Citations

Nov 18, 2021·The Cochrane Database of Systematic Reviews·Hanna BergmanKarla Soares-Weiser

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT02907216

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