Immunogenicity and tolerability of yellow fever vaccination in 23 French HIV-infected patients

Current HIV Research
Thierry PistoneDenis Malvy

Abstract

Vaccination of asymptomatic human immunodeficiency virus (HIV)-infected patients with a CD4 cell count ≥ 200/mm³ is strongly suggested prior to travel to a region where yellow fever (YF) is endemic. However, few data describing YF vaccination in such patients are available. In this retrospective observational study of 23 HIV-infected patients, YF antibody titers, CD4 cell counts, and viral loads were measured before and after vaccination. Serologies were performed retrospectively on samples that had been stored as part of routine hospital procedures. Ninety-three percent of patients (13/14) with no baseline immunity, seroconverted after vaccination. Immunogenicity appeared slowly; only 2 of the 5 patients tested within 5 weeks of vaccination had seroconverted. A booster effect was noted in 3 of the 9 patients with baseline immunogenicity. Finally, due to unawareness of his HIV status, one patient was vaccinated and was found later to have a CD4 cell count < 200/mm³.The YF vaccine was well tolerated and no serious adverse events were reported. The impact of vaccination on immunologic and viral parameters was variable. Both decreases (n = 7) and increases (n = 5) in CD4 cell counts were recorded. Viral loads became undetectable i...Continue Reading

Citations

May 26, 2012·Transactions of the Royal Society of Tropical Medicine and Hygiene·Mariam SidibeOlivia Veit
Feb 4, 2012·The American Journal of Tropical Medicine and Hygiene·Roger E ThomasTyler Williamson
Jul 17, 2014·AIDS Patient Care and STDs·Nancy F Crum-Cianflone, Mark R Wallace
Sep 12, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Vivian I Avelino-SilvaEsper G Kallas
Nov 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L S AzevedoE David-Neto
Apr 15, 2015·Current Infectious Disease Reports·Charlotte M Verolet, Klara M Posfay-Barbe
Sep 6, 2013·The American Journal of Tropical Medicine and Hygiene·Eduardo GotuzzoErika Córdova
Nov 16, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Olivia VeitUNKNOWN Swiss HIV Cohort Study
Aug 11, 2018·AIDS·Nathalie Colin de VerdiereUNKNOWN ANRS EP46 NOVAA Group
Jan 24, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jérôme PacanowskiPierre-Marie Girard
Aug 7, 2017·Infectious Diseases and Therapy·Nancy F Crum-Cianflone, Eva Sullivan
Mar 5, 2013·Canada Communicable Disease Report = Relevé Des Maladies Transmissibles Au Canada·This Statement Was Prepared By P Charlebois, UNKNOWN approved by CATMAT.
Dec 13, 2016·PLoS Neglected Tropical Diseases·Vivian I Avelino-SilvaEsper G Kallas
Apr 5, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Charlotte MartinNicolas Dauby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M C ReceveurM L Bras
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Olivia VeitSwiss HIV Cohort Study
AIDS Patient Care and STDs
Yeh Li HoSigrid De Sousa Dos Santos
© 2021 Meta ULC. All rights reserved