Immunogenicity and vaccine potential of dipeptidic multiple antigen peptides from Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase

Scandinavian Journal of Immunology
Rashika El RidiHatem Tallima

Abstract

Six peptides, A, B1, B, C, D and E, derived from the primary sequence of Schistosoma mansoni glyceraldehyde 3-phosphate dehydrogenase (SG3PDH) were selected based on lowest homology to human glyceraldehyde 3-P dehydrogenase (G3PDH), multimerized in dipeptidic multiple antigen peptide (D-MAP) constructs and used for the immunization of BALB/c mice. Tetrabranched D-MAPs A-B, B1-C and D-E and the bis-D-MAP B-E elicited strong cell-mediated and antibody responses against immunogen, unit peptides and their cognate sequences in the native and denatured protein. D-MAP A-B induced protection against challenge infection. Immunization with D-MAP B1-C failed to affect the challenge worm parameters, probably because peptides B1 and C, previously shown to elicit immune responses associated with increase and decrease in challenge worm fertility, respectively, induced immune responses with opposing effects when combined in a D-MAP construct. A similar suggestion may explain the failure of D-MAP D-E to protect the host against challenge infection. In contrast, immunization with D-MAP B-E resulted in robust protection of the host, possibly because it contains peptides known to evoke immune responses associated with a significant decrease in cha...Continue Reading

References

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Citations

Oct 1, 2005·Journal of Peptide Science : an Official Publication of the European Peptide Society·Petr NiederhafnerJan Jezek
Mar 28, 2006·Cytokine·Rashika El RidiHatem Tallima
Sep 1, 2013·Journal of Advanced Research·Rashika A F El Ridi, Hatem A-M Tallima
May 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·András KolozsiBéla Gyurcsik
Oct 30, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David PirovichPatrick J Skelly
May 4, 2021·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Aya Al-NaseriNoha Mahana

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