Immunogenicity of a recombinant MVA and a DNA vaccine for Japanese encephalitis virus in swine

Microbiology and Immunology
Jae-Hwan NamHae-Wol Cho

Abstract

We previously reported that mice immunized with recombinant modified vaccinia virus Ankara (MVA) encoding Japanese encephalitis virus (JEV) prM and E genes were completely protected against JEV challenge (Nam, J.H., Wyatt, L.S., Chae, S.L., Cho, H.W., Park, Y.K., Moss, B. Vaccine 1999,17: 261-268). In this study, we examined the immunogenicity in swine of this recombinant MVA (vJH9) or a DNA vaccine (pcJH-1) expressing the same JEV genes. Although the booster effect in mice with a combination of vJH9, pcJH-1 and inactivated JEV commercial vaccine was not apparent by measuring JEV antibodies, the recombinant MVA vaccine (vJH9) and the DNA vaccine (pcJH-l) efficiently produced neutralizing antibodies in swine and 2 doses of each showed a booster effect in mice and swine. Therefore, both vJH9 and pcJH-1 are good candidates for a second generation JEV vaccine.

References

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Citations

Mar 11, 2004·Veterinary Immunology and Immunopathology·C C BreathnachD P Lunn
May 15, 2010·Journal of Biomedicine & Biotechnology·Penelope KorakaAlbert D M E Osterhaus
Apr 9, 2015·Viruses·Lucas Sánchez-SampedroMariano Esteban
Dec 18, 2007·Expert Opinion on Biological Therapy·David W C BeasleyTom Solomon
Sep 6, 2008·Developmental and Comparative Immunology·Kenneth C McCullough, Artur Summerfield
Jan 8, 2014·The American Journal of Tropical Medicine and Hygiene·Natalie B CletonRichard A Bowen
Jan 13, 2015·The Journal of General Virology·Xiao-Dan LiBo Zhang

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