Immunogenicity of a single dose of meningococcal group C conjugate vaccine given at 3 months of age to healthy infants in the United kingdom

The Pediatric Infectious Disease Journal
Helen FindlowElizabeth Miller

Abstract

From 1999, in the United Kingdom, meningococcal C conjugate (MCC) vaccines from 3 manufacturers were introduced to the infant immunization schedule at 2, 3 and 4 months of age. In 2006, the schedule was refined to a 2-dose primary schedule at 3 and 4 months of age, with a combined MCC/Haemophilus influenzae type b (MCC/Hib-TT) booster at 12 months of age. Recent data have demonstrated that 2 of the 3 MCC vaccines showed potential for use as a single priming dose in infancy. A randomized trial was undertaken with 2 MCC vaccines; one using tetanus toxoid carrier protein (MCC-TT) and one using CRM197 carrier protein (MCC-CRM197). Infants were immunized with MCC at 3 months of age followed by an MCC/Hib-TT booster at 12 months of age. The serum bactericidal antibody geometric mean titers 1 month after a single dose of MCC-TT or MCC-CRM 197 were 223.3 (95% confidence interval [CI]: 162.9-306.1) and 95.8 (95% CI: 66.4-138.2) with 100% and 95.5% of infants having serum bactericidal antibody titers ≥ 8, respectively. Before boosting, antibody titers had declined, and 1 month after the MCC/Hib-TT booster, serum bactericidal antibody geometric mean titers rose to 2251.0 (95% CI: 1535.3-3300.3) and 355.9 (95% CI: 235.4-538.1) for children...Continue Reading

References

Jun 1, 1983·The Journal of Infectious Diseases·H KäyhtyP H Mäkelä
Mar 29, 2006·The Pediatric Infectious Disease Journal·David GoldblattElizabeth Miller
Jul 6, 2010·Vaccine·Ron DaganClaire-Anne Siegrist
Jul 28, 2010·The Pediatric Infectious Disease Journal·Noga Givon-LaviRon Dagan

❮ Previous
Next ❯

Citations

Jan 15, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Moreno-PérezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría
Jan 15, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J Arístegui FernándezUNKNOWN en representación del Comité Asesor de Vacunas de la Asociación Española de Pediatría
Dec 11, 2014·Expert Review of Vaccines·Marco Aurélio SáfadiUNKNOWN Global Meningococcal Initiative
Sep 21, 2012·Expert Opinion on Biological Therapy·David Pace
Dec 17, 2014·Expert Opinion on Biological Therapy·Mairi Vella, David Pace
Mar 5, 2016·Human Vaccines & Immunotherapeutics·Michael BrökerPaolo Costantino
Sep 6, 2012·Tropical Medicine & International Health : TM & IH·Ray Borrow
Sep 17, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shamez N LadhaniElizabeth Miller
Apr 29, 2015·Human Vaccines & Immunotherapeutics·Helen Findlow, Ray Borrow
May 16, 2013·Vaccine·Eva-Maria PoellabauerHartmut J Ehrlich
Aug 13, 2013·Vaccine·Ray BorrowJulio A Vazquez
May 15, 2015·JRSM Open·Christina J Atchison, Sondus Hassounah
May 15, 2015·Journal of Clinical Microbiology·Andries J van TonderAngela B Brueggemann
Aug 22, 2012·Current Opinion in Infectious Diseases·Jakob P Cramer, Annelies Wilder-Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.