PMID: 7544369May 1, 1995Paper

Immunogenicity of biliary epithelial cells: study of the expression of B7 molecules

Journal of Hepatology
M P LeonM F Bassendine

Abstract

Efficient antigen presentation requires the provision of a co-stimulatory signal, the best characterized of which is provided by the B7 molecules. It is unclear whether biliary epithelial cells expressing Class II major histocompatibility complex molecules can function as antigen presenting cells, although this has been suggested as an important mechanism in the initiation and/or perpetuation of some immune-mediated liver diseases, including primary biliary cirrhosis and liver allograft rejection. We have found that human intrahepatic biliary epithelial cells do not express B7-1 (CD80) or B7-2 in vitro, even after activation with high doses of interferon-gamma, tumour necrosis factor-alpha or phorbol myristate acetate, or in vivo. However, they express similar levels of class II major histocompatibility complex antigens to those expressed by professional antigen presenting cells (Epstein-Barr virus transformed B cells). It is therefore unlikely that biliary epithelial cells stimulate efficient primary T cell activation. It may be possible that these non co-stimulatory class II major histocompatibility complex positive cells play a role in modulating immune responses in the liver.

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Citations

Aug 27, 1998·In Vitro Cellular & Developmental Biology. Animal·K YahagiT Toyota
Jun 5, 2003·Journal of Pediatric Surgery·Hiroyuki KobayashiTakeshi Miyano
Dec 22, 1999·Journal of Hepatology·S M CruickshankL K Trejdosiewicz
Aug 8, 2002·Clinical and Experimental Immunology·J M PalmerD E J Jones
Jul 1, 1997·Journal of Gastroenterology and Hepatology·K KajiK Kobayashi
Feb 16, 2000·Journal of Clinical Pathology·S M CruickshankL K Trejdosiewicz
Sep 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gaurav SyalJonathan A Dranoff
Aug 28, 2010·Journal of Gastroenterology·Ana LleoM Eric Gershwin
Dec 1, 1996·The Journal of Laboratory and Clinical Medicine·W HuH L Sharp
Jan 24, 2007·Gastroenterology·Domenico AlvaroGianfranco Alpini
Feb 19, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ana Lleo, Pietro Invernizzi
Feb 6, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J DemetrisD B Stolz
Dec 1, 1996·The Journal of Laboratory and Clinical Medicine·D H Adams
Dec 7, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Karolina A RygielJohn A Kirby
Apr 30, 2020·Journal of Leukocyte Biology·Vincenzo RoncaPietro Invernizzi
Apr 13, 2018·Frontiers in Immunology·Christina MehrfeldVeronika Lukacs-Kornek

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