Immunogenicity of biologic agents in juvenile idiopathic arthritis: a systematic review and meta-analysis

Rheumatology
Martijn J H DoelemanJoost F Swart

Abstract

The clinical impact of anti-drug antibodies (ADAbs) in paediatric patients with JIA remains unknown. This systematic review and meta-analysis aimed to summarize the prevalence of ADAbs in JIA studies; investigate the effect of ADAbs on treatment efficacy and adverse events; and explore the effect of immunosuppressive therapy on antibody formation. PubMed, Embase and the Cochrane Library were systematically searched to identify relevant clinical trials and observational studies that reported prevalence of ADAbs. Studies were systematically reviewed in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses and appropriate proportional and pairwise meta-analyses were performed. A total of 5183 references were screened; 28 articles, involving 26 studies and 2354 JIA patients, met eligibility criteria. Prevalence of ADAbs ranged from 0% to 82% across nine biologic agents. Overall pooled prevalence of ADAbs was 16.9% (95% CI, 9.5, 25.9). Qualitative analysis of included studies indicated that antibodies to infliximab, adalimumab, anakinra and tocilizumab were associated with treatment failure and/or hypersensitivity reactions. Concomitant MTX uniformly reduced the risk of antibody formation during adal...Continue Reading

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Citations

Oct 23, 2019·Expert Review of Clinical Immunology·Andrea MatucciAlessandra Vultaggio
Feb 14, 2020·Paediatric Drugs·Zaid H TemrikarBernd Meibohm
Oct 6, 2019·Rheumatology·William D Renton, Athimalaipet V Ramanan
Nov 11, 2019·Clinical Rheumatology·Juliana Barbosa BrunelliNádia Emi Aikawa
May 16, 2020·Medicina·Francesca MoriCarlo Caffarelli
Sep 5, 2020·Paediatric Drugs·John M Bridges, Matthew L Stoll
Feb 20, 2021·Frontiers in Pharmacology·Varvara ChoidaCoziana Ciurtin
Jul 6, 2020·Seminars in Arthritis and Rheumatism·Naomi Schlesinger, Peter E Lipsky
Jan 21, 2022·Ocular Immunology and Inflammation·Annie XiaUwe Pleyer

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