Immunogenicity of BNT162b2 mRNA COVID-19 vaccine and SARS-CoV-2 infection in lung transplant recipients.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Jan HavlinPetr Hubacek

Abstract

The immunogenicity of the novel mRNA COVID-19 vaccine in immunocompromised lung transplant recipients is still unknown. We compared the antibody response after the first and second doses of the BNT162b2 mRNA COVID-19 vaccine (Pfizer-BioNTech) with the response after natural SARS-CoV-2 infection in lung transplant recipients. None of the vaccinees tested after two doses of the mRNA BNT162b2 vaccine developed anti-SARS-CoV-2 IgG, while 85% patients presented an antibody response after SARS-CoV-2 infection. The absence of antibody response to vaccination led us to investigate the cellular response in a subset of patients. We detected SARS-CoV-2 specific T-cells in 4 out of 12 tested patients. Some patients therefore might have clinical benefit from the vaccine despite an absent antibody response. These results contrast with the excellent antibody response in immunocompetent individuals observed in mRNA BNT162b2 trials and indicate an urgent need to identify the best vaccine type and scheme for immunocompromised transplanted patients.

References

Jun 11, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Catherine N MyersUNKNOWN Temple University COVID-19 Research Group
Sep 4, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Meghan AversaUNKNOWN From the Columbia University Lung Transplant Program

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Citations

Jun 20, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Saima AslamMandeep R Mehra
Jun 30, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Mario PlebaniAndrea Padoan
Jul 3, 2021·Vaccines·Madhusudhanan NarasimhanAlagarraju Muthukumar
Jul 19, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tina MarinelliDeepali Kumar
Jul 31, 2021·Expert Review of Clinical Pharmacology·Samantha ScharringaGer T Rijkers
Jul 30, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Saima AslamSusan J Little
Jul 23, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sabina HerreraMarta Bodro
Aug 5, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Victoria G HallDeepali Kumar
Aug 13, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
Aug 31, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andrew M HallettErrol L Bush
Aug 28, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Maddalena GiannellaOriol Manuel
Sep 23, 2021·The New England Journal of Medicine·Tamara PilishviliUNKNOWN Vaccine Effectiveness among Healthcare Personnel Study Team
Sep 8, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Silvia MeschiUNKNOWN INMI Covid-19 laboratory and investigation team
Dec 3, 2021·Expert Review of Anti-infective Therapy·Paraskevas FilippidisMatteo Mombelli

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