PMID: 6761343Jan 1, 1982

Immunogenicity of cellular and acellular antigen preparations from a methylcholanthrene-induced mouse sarcoma

Journal of Cancer Research and Clinical Oncology
K HöffkenC G Schmidt

Abstract

Inbred mice were immunized with various cellular and subcellular preparations from a syngeneic, methylcholanthrene-induced sarcoma to induce transplantation immunity against a subsequent challenge of viable cells from the same tumor. Only with conventional immunization procedures using radiation-attenuated tumor cells or viable tumor cells in admixture with bacillus Calmette-Guérin was transplantation immunity obtained. Neither native soluble tumor extracts prepared using several extraction methods, nor cross-linked preparations of these extracts gave rise to transplantation immunity. With few exceptions, however, the immunizing preparations resulted in the production of tumor-specific humoral antibody. The manner in which tumor antigens are presented to the host as well as the experimental system (animal strain; tumor) used appear to play an important role in the development of transplantation immunity against tumors.

References

Dec 23, 1977·Biochimica Et Biophysica Acta·R B Herberman
Jun 1, 1975·Journal of the National Cancer Institute·M S MeltzerH J Rapp
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·M ZöllerR W Baldwin
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·M J Embleton
Jan 1, 1973·Advances in Cancer Research·R W Baldwin
Jun 21, 1971·Annals of the New York Academy of Sciences·R W BaldwinM V Pimm
Nov 1, 1973·British Journal of Cancer·R W BaldwinM Moore
Mar 15, 1973·International Journal of Cancer. Journal International Du Cancer·R W BaldwinM R Price
May 1, 1973·Analytical Biochemistry·P W Holloway
Oct 1, 1973·British Journal of Cancer·R W Baldwin, M V Pimm
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·M V PimmR W Baldwin

Related Concepts

Metazoa
Antibody Formation
Tumor Antigens
BCG Vaccine
Cross-Linking Reagents
Immunofluorescence Assay
Methylcholanthrene
Mice, Inbred Strains
Sarcoma, Spindle Cell
Transplantation Immunology

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