Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans.

Science Advances
P J KlasseJohn P Moore

Abstract

Multiple preventive vaccines are being developed to counter the coronavirus disease 2019 pandemic. The leading candidates have now been evaluated in nonhuman primates (NHPs) and human phase 1 and/or phase 2 clinical trials. Several vaccines have already advanced into phase 3 efficacy trials, while others will do so before the end of 2020. Here, we summarize what is known of the antibody and T cell immunogenicity of these vaccines in NHPs and humans. To the extent possible, we compare how the vaccines have performed, taking into account the use of different assays to assess immunogenicity and inconsistencies in how the resulting data are presented. We also review the outcome of challenge experiments with severe acute respiratory syndrome coronavirus 2 in immunized macaques, while noting variations in the protocols used, including but not limited to the virus challenge doses. Press releases on the outcomes of vaccine efficacy trials are also summarized.

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Citations

Mar 12, 2021·Cell Host & Microbe·Rogier W Sanders, John P Moore
Jun 3, 2021·The New England Journal of Medicine·Nathalie E BlachereRobert B Darnell
Jun 12, 2021·Human Vaccines & Immunotherapeutics·Javier Burgos-Salcedo
Jul 3, 2021·Pathogens·Zainalabideen A AbdullaMohammad Z Abdulazeez
Jul 3, 2021·Vaccines·Matthieu Van TilbeurghCaroline Manet
Jun 26, 2021·Frontiers in Immunology·Cong SunMu-Sheng Zeng
Jul 28, 2021·Communications Biology·Teresa LambeSarah C Gilbert
Jul 7, 2021·Bioconjugate Chemistry·Ian W Hamley
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Aug 29, 2021·Vaccines·Laure AlbrechtCaroline Passaes
Aug 30, 2021·Indian Journal of Medical Microbiology·Jobin John JacobAnkur Mutreja
Sep 18, 2021·Nature Immunology·John P Moore, Celine R Gounder
Aug 29, 2021·Journal of the National Cancer Institute·Hagai LigumskyIdo Wolf

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