Immunogenicity of gonococcal Gc2 polysaccharide: comparative studies with pneumococcal type III polysaccharide and Salmonella typhosa Vi antigen.

Infection and Immunity
J F Breen, M A Apicella

Abstract

A plaque assay technique was used to assess the immunogenicity of a gonococcal cell wall polysaccharide (Gc2 antigen) in BALB/c mice. The Gc2 antigen was shown to be immunogenic, and the kinetics of the response differed from that of a pneumococcal polysaccharide (SSS-III) and a polysaccharide antigen of Salmonella typhosa (Vi antigen). In addition, using antithymocyte sera, the T-lymphocyte dependency of these antigens was investigated. The immune response to the Gc2 antigen was demonstrated to be dependent on a population of helper T cells, whereas the response to SSS-III appears to be regulated by suppressor T cells. There appears to be marked differences in the immune response of mice to different bacterial polysaccharides.

References

Mar 1, 1973·Infection and Immunity·M A Apicella, J C Allen
Jun 1, 1973·The Journal of Experimental Medicine·P J BakerB Prescott
Oct 1, 1972·Applied Microbiology·K H Wong, J C Feeley

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Citations

Oct 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E Rødahl, J A Maeland
Nov 20, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L MarshallAdam F Cunningham

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