PMID: 9537270Apr 16, 1998Paper

Immunogenicity of Haemophilus influenzae-diphtheria CRM197 protein conjugate vaccine (HbOC) in Libyan infants

Tropical Medicine & International Health : TM & IH
M HadidaC A Hart

Abstract

The immunogenicity of the HbOC, a Haemophilus influenzae type b conjugate vaccine, was evaluated in a randomized clinical trial of Arab children resident in Tripoli. The HbOC vaccine was given as part of a three-dose series at 2, 3 and 4 months of age together with hepatitis B, OPV and DPT to 90 children. Anti-H. influenzae antibody levels were compared with 81 infants receiving hepatitis B, OPV and DPT but not the HbOC vaccine. The immunogenicity and safety of HbOC was as high as that observed in industrialised countries. There were no major complications, and fever and temporary local discomfort were observed in fewer than approximately 2% of the infants. Infants receiving the HbOC vaccine had an increase in Hib antibodies with only one dose. Geometric mean anti-Hib antibody levels were 0.41, 1.36 and 2.91 mg/ml after one, two and three doses. After two doses, all children had antibody levels above 0.20 mg/ml and the lowest antibody concentration was 0.80 mg/ml. Antibody levels in our children are similar to those observed in Europe and the USA and it is thus likely that HbOC will provide good clinical protection in this population. As most of the children develop antibody titres above or near 1 mg/ml, it is likely that they ...Continue Reading

References

Nov 1, 1992·Indian Journal of Pediatrics·H A SrairM al-Khater
Jun 1, 1992·The Journal of Infectious Diseases·K E Stein
Feb 1, 1992·The Journal of Pediatrics·M D DeckerP Palmer
Jan 1, 1991·Epidemiologic Reviews·E D Shapiro, J I Ward
Jun 1, 1983·The Journal of Infectious Diseases·H KäyhtyP H Mäkelä
Aug 1, 1995·Archives of Otolaryngology--head & Neck Surgery·O P AlhoH Oja
Sep 17, 1994·Lancet·S ZielenD Hofmann
Jul 1, 1994·The Pediatric Infectious Disease Journal·O Castillo de FebresK M Edwards
Jan 1, 1993·The American Journal of Tropical Medicine and Hygiene·N I GirgisZ Farid

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Citations

Apr 26, 2000·Canadian Journal of Microbiology·S MiyazakiK Yamaguchi

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