Immunogenicity of kappa-casein and glycomacropeptide

Journal of Dairy Science
Trine L MikkelsenH Frøkiaer

Abstract

Glycomacropeptide (GMP), arising from the cleavage of kappa-casein by chymosin or pepsin, has been correlated with a wide variety of biological activities including immunosuppression capacity, inhibition of pathogen invasion, and induction of satiety. Due to the interest in exploiting such potential of GMP, we aimed at characterizing the immunogenic properties of GMP as an indication of its potential allergenicity. Immunogenicity of kappa-casein and GMP were investigated using 2 animal models based on different routes of immunization: 1) mice immunized intraperitoneally or subcutaneously with either kappa-casein, polymerized GMP, GMP coupled to the immunogenic carrier ovalbumin, or GMP alone; 2) mice coadministered kappa-casein or GMP and cholera toxin. The specific antibody response to GMP was evaluated as well as the antigen-specific T-cell response. The results demonstrated that immunization or feeding with kappa-casein induced GMP-specific antibodies, whereas GMP per se lacked immunogenicity independently of the mode of presentation. The size of the presented form of GMP did not influence its immunogenicity. Because the results showed that GMP did not induce a specific T-cell response, we postulate that GMP lacks the abilit...Continue Reading

References

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Citations

Oct 26, 2011·Journal of Drug Targeting·Carla G MoutinhoVictor M Balcão
Jan 13, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nuria Renata RoldánEva Salinas
Jan 27, 2019·Current Protein & Peptide Science·Fengtao MaPeng Sun
May 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniel Cervantes-GarcíaEva Salinas

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