Immunogenicity of novel mumps vaccine candidates generated by genetic modification

Journal of Virology
Pei XuBiao He

Abstract

Mumps is a highly contagious human disease, characterized by lateral or bilateral nonsuppurative swelling of the parotid glands and neurological complications that can result in aseptic meningitis or encephalitis. A mumps vaccination program implemented since the 1960s reduced mumps incidence by more than 99% and kept the mumps case numbers as low as hundreds of cases per year in the United States before 2006. However, a large mumps outbreak occurred in vaccinated populations in 2006 and again in 2009 in the United States, raising concerns about the efficacy of the vaccination program. Previously, we have shown that clinical isolate-based recombinant mumps viruses lacking expression of either the V protein (rMuVΔV) or the SH protein (rMuVΔSH) are attenuated in a neurovirulence test using newborn rat brains (P. Xu et al., Virology 417:126-136, 2011, http://dx.doi.org/10.1016/j.virol.2011.05.003; P. Xu et al., J. Virol. 86:1768-1776, 2012, http://dx.doi.org/10.1128/JVI.06019-11) and may be good candidates for vaccine development. In this study, we examined immunity induced by rMuVΔSH and rMuVΔV in mice. Furthermore, we generated recombinant mumps viruses lacking expression of both the V protein and the SH protein (rMuVΔSHΔV). Ana...Continue Reading

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Citations

Dec 14, 2017·The New England Journal of Medicine
Jan 1, 2019·Uirusu·Minoru Kidokoro
Dec 15, 2017·The New England Journal of Medicine·Bryant J WebberAmy A Costello
Aug 5, 2019·World Journal of Pediatrics : WJP·Duo ZhouZheng-Yan Zhao
Sep 26, 2020·Frontiers in Microbiology·Iman Almansour
Oct 20, 2020·Frontiers in Immunology·Anna R ConnellJaythoon Hassan

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