Immunogenicity of pneumococcal vaccination of patients with cochlear implants

The Journal of Infectious Diseases
Markus RoseStefan Zielen

Abstract

Pneumococcal meningitis is a rare but potentially fatal complication of cochlear implantation. A prospective study was conducted of the immunogenicity of pneumococcal vaccination in 174 patients with cochlear implants (CIs). The cohort was divided into groups of patients with impaired hearing due to meningitis (P(1)), cranial malformations (P(2)), or an unknown cause (P(3)) and was stratified by age as follows: <2 years (A(1)), 2-5 years (A(2)), and >5 years (A(3)). We determined immunoglobulin (Ig) levels for IgG subclasses 1-4 and serum concentrations of antibodies against pneumococci before and 4-6 weeks after vaccination. Group A(1) received the 7-valent pneumococcal conjugate vaccine (PCV-7), group A(2) received PCV-7 or the 23-valent pneumococcal polysaccharide vaccine (PPV-23), and group A(3) received PPV-23. IgG, IgM, and IgG1 levels were significantly lower in group P(1), compared with the other patient groups and with historic data for healthy control subjects, suggesting a decreased antibody response. Group P(1) had lower levels of pneumococcal antibodies, compared with groups P(2) and P(3) before vaccination (P<.05, pneumococcal serotypes 4 and 9V). Irrespective of the underlying condition, all patients showed a suf...Continue Reading

Citations

Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin P C WeiStephen J O'Leary
Nov 1, 2006·International Journal of Clinical Practice·M A RoseS Zielen
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Oct 7, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C SpeckmannS Ehl
Nov 26, 2008·International Journal of Pediatric Otorhinolaryngology·Attila TorkosJózsef Jóri
Oct 7, 2009·Expert Review of Vaccines·Markus Rose, Stefan Zielen
Mar 10, 2018·The Laryngoscope·Anita JeyakumarBrian J McKinnon
Sep 9, 2005·The Laryngoscope·Christiane HeyStefan Zielen
Oct 7, 2005·Expert Review of Anti-infective Therapy·E David G McIntosh
Jun 18, 2015·Expert Review of Vaccines·Mark A FletcherNathalie Dartois
Aug 8, 2014·Current Opinion in Otolaryngology & Head and Neck Surgery·Charissa N KahueDavid S Haynes
Jul 28, 2010·Pediatrics·Lorry G RubinUNKNOWN Committee on Infectious Diseases and Section on Otolaryngology-Head and Neck Surgery

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