Immunogenicity of two doses of yeast recombinant hepatitis B vaccine in healthy older adults

The Journal of Infectious Diseases
B G GellinM L Clements-Mann

Abstract

To determine the immunogenicity of two doses of yeast recombinant hepatitis B virus (HBV) vaccine containing surface (S) protein, an open-label, multicenter trial was conducted in 199 healthy HBV-seronegative adults > or = 40 years old. Volunteers were randomly assigned to 1 of 5 groups to receive a total of three 10-microg doses, at 0, 1, and 6 months, or a total of two doses of 20 microg and 10 microg, 20 microg and 20 microg, 40 microg and 10 microg, or 40 microg and 20 microg at 0 and 6 months. The 40-microg/20-microg regimen elicited the highest rate of seroprotection (96.2%), with a geometric mean titer of antibody against the S protein of 369 mIU/mL, not significantly different from the 536 mIU/mL achieved with three doses. These results suggest that a two-dose regimen can achieve seroprotection similar to that of the three-dose regimen. Whether a shorter interval can be used or a booster dose will be needed later to confer durable immunity are unknown.

Citations

Jun 5, 2003·International Journal for Parasitology·John DonnellyJeffrey B Ulmer
Jul 27, 1999·Vaccine·J N Wilson, D J Nokes
Oct 4, 2007·Sexually Transmitted Infections·K Van HerckP Van Damme
Jun 23, 2009·Trends in Immunology·Wilbur H ChenMarcelo B Sztein
May 7, 2014·Journal of Travel Medicine·Jason WongSusan Hollenberg
Dec 2, 1998·Sozial- Und Präventivmedizin·D Desgrandchamps, C A Siegrist
Jan 5, 2021·Human Vaccines & Immunotherapeutics·Firzan NainuHarapan Harapan

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