Immunogenicity of xenopeptide hormone therapies

Peptides
Catherine A SchnabelDennis D Kim

Abstract

Peptides are a growing class of agents whose therapeutic use originated with non-human treatments such as animal insulins. Xenopeptides continue to be explored for biotherapeutic development using genetic engineering, and through the rich resource of animal and plant polypeptides. One of the major concerns of therapeutic administration of xenopeptides is the potential for untoward immune responses that may lead to loss of drug efficacy or adverse events in recipients. An increased risk of immunogenicity is perceived with xenopeptides, however, human-derived therapies also induce antibody formation that in some cases has been associated with severe clinical sequelae. In this review, antibody responses to xenopeptides are highlighted looking at current hormone therapies used to treat endocrine disorders. Similar to clinical experiences with peptide-based agents in general, antibody responses against xenopeptide hormone therapies in majority of cases have been benign in nature with minimal clinical impact.

References

Feb 1, 1979·Australian and New Zealand Journal of Medicine·T J Martin
Feb 1, 1991·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R MuffJ A Fischer
Jan 1, 1991·Calcified Tissue International·F R Singer
Jul 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·O IshibashiY Shigeta
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·F LevyJ A Fischer
Jun 1, 1985·Diabetes·T Deckert
Feb 1, 1967·The Journal of Clinical Investigation·N FleischerW E Nicholson
Sep 1, 1972·The Journal of Clinical Investigation·F R SingerK J Bloch
Jan 1, 1971·Current Topics in Experimental Endocrinology·J T PottsL J Deftos
Jan 19, 1967·The New England Journal of Medicine·R A MelickG D Aurbach
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·J T PottsL J Deftos
Oct 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·H D NiallJ T Potts
Jun 1, 1966·The Journal of Clinical Endocrinology and Metabolism·J RothM J Petersen
May 1, 1966·The American Journal of Medicine·L F Smith
Jul 1, 1984·Diabetic Medicine : a Journal of the British Diabetic Association·P D HomeW G Reeves
Dec 1, 1983·Diabetologia·S E FinebergS Hufferd
Apr 1, 1984·Journal of Endocrinological Investigation·V Lo CascioL A Scuro
Feb 1, 1982·Diabetologia·S WalfordW G Reeves
Sep 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A GrauerF Raue
Sep 1, 1993·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J Y ReginsterP Franchimont
Apr 29, 1998·The Journal of Clinical Investigation·J SchirraM Katschinski
Jan 5, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·M G Jacquemin, J M Saint-Remy
Apr 25, 2001·Metabolism: Clinical and Experimental·D G ParkesA Young
Jun 19, 2001·American Journal of Physiology. Endocrinology and Metabolism·C M EdwardsS R Bloom
Jul 5, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·E BosiM Salvi

❮ Previous
Next ❯

Citations

Jun 29, 2010·Indian Journal of Pharmaceutical Sciences·C K Chakraborti
Nov 1, 2010·Expert Opinion on Drug Discovery·Andreas Nechansky, Ralf Kircheis
Aug 27, 2010·Journal of Pharmaceutical Sciences·Satish Kumar Singh
Apr 2, 2016·Journal of Immunology Research·Lin-Zhi ChenElsy Philip
Jul 7, 2009·Peptides·Peter FaludiDaniel K Braun
Nov 22, 2015·Clinical Endocrinology·Jean L ChanRebecca J Brown
Oct 30, 2015·Diabetes, Obesity & Metabolism·Sten Madsbad
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Milena DeptułaMichał Pikuła
Sep 20, 2007·Biomacromolecules·Bruno SarmentoRonald Neufeld

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.