PMID: 9557157Apr 29, 1998Paper

Immunoglobulin- and hepatitis B surface antigen-specific circulating immune complexes in chronic hepatitis B virus infection

Clinical Immunology and Immunopathology
J F TsaiJ H Tsai

Abstract

For assessing the role of circulating immune complexes (CIC) in chronic hepatitis B virus (HBV) infection, CICs containing IgM, IgG, and HBsAg were determined by C1q and conglutinin (K) assays in 216 patients with chronic HBV infection and 54 healthy controls. The concentration of each type of CIC in patients is higher than in controls (P = 0.0001). CIC is a common feature of chronic HBV infection with 95.8% of cases having at least one abnormal test result. At least one type of HBsAg-CIC is positive in 54.2% of patients. HBsAg-CIC positivity is associated with HBeAg positivity (P = 0.0001), higher aminotransferase levels (P < 0.002), and younger age (P = 0.001). IgG-CIC or IgM-HBsAg-CIC correlates with higher aminotransferase activity (P = 0.001). In conclusion, HBsAg-CIC correlates with HBV replication. IgG-CIC and/or IgM-HBsAg-CIC correlate with disease activity. Immune-mediated injury may play a role in the pathogenesis of chronic HBV infection.

References

Aug 24, 1987·Journal of Immunological Methods·H S MargolisD W Bradley
Dec 1, 1986·Clinical Immunology and Immunopathology·R VeerhuisM R Daha
Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C L Troisi, F B Hollinger
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Celis, T W Chang
Apr 1, 1995·Clinical Immunology and Immunopathology·J F TsaiJ H Tsai
Jan 1, 1995·Annual Review of Immunology·F V Chisari, C Ferrari
May 1, 1995·Journal of Medical Virology·J F TsaiJ H Tsai
Jan 1, 1993·Gut·C TrépoL Vitvitski
Mar 1, 1996·Clinical Immunology and Immunopathology·J F TsaiJ H Tsai
Jul 1, 1996·Baillière's Clinical Gastroenterology·F Bortolotti

❮ Previous
Next ❯

Citations

Jun 26, 2001·Journal of Medical Virology·B WeberH Rabenau
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ji-Ming ZhangMengji Lu
Oct 19, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wai Po ChongYu Lung Lau
Dec 13, 2006·Travel Medicine and Infectious Disease·Franco Giovanetti
Sep 14, 2010·Journal of Immunological Methods·Thomas Krogh-MeibomUffe Holmskov
Jan 23, 2008·Multiple Sclerosis : Clinical and Laboratory Research·John ParrattRobert Swingler
Mar 31, 2006·European Journal of Immunology·Tomás Hanke
Mar 12, 2019·Virology·Tetyana LukashSeverin O Gudima

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.