Immunoglobulin A and liver diseases

Journal of Gastroenterology
Tatsuo Inamine, Bernd Schnabl

Abstract

Immunoglobulin A (IgA) is a major immunoglobulin isotype in the gut and plays a role in maintenance of gut homeostasis. Secretory IgA (SIgA) has multiple functions in the gut, such as to regulate microbiota composition, to protect intestinal epithelium from pathogenic microorganisms, and to help for immune-system development. The liver is the front-line organ that receives gut-derived products through the portal vein, implying that the liver could be severely affected by a disrupted intestinal homeostasis. Indeed, some liver diseases like alcoholic liver disease are associated with an altered composition of gut microbiota and increased blood endotoxin levels. Therefore, deficiency of SIgA function appears as a significant factor for the pathogenesis of liver diseases associated with altered gut microbiome. In this review, we describe SIgA functions on the gut microbiome and discuss the role of IgA for liver diseases, especially alcoholic liver disease and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.

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Citations

Oct 27, 2018·Journal of Pediatric Gastroenterology and Nutrition·Marialena MouzakiStavra A Xanthakos
Dec 11, 2019·Nature Reviews. Gastroenterology & Hepatology·Aliya F Gulamhusein, Gideon M Hirschfield
Jun 19, 2019·Journal of Animal Science and Biotechnology·Diana LuisePaolo Trevisi
Jul 28, 2020·International Journal of Molecular Sciences·Aleksandar ArsenijevicMarija Milovanovic
Oct 29, 2020·Cellular & Molecular Immunology·Andrea Kristina HorstGisa Tiegs
Nov 14, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xuemei GuZhongbin Deng
Jun 23, 2020·Gastroenterology·Daniel M Chopyk, Arash Grakoui

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