Immunoglobulin A and microbiota in primary immunodeficiency diseases

Current Opinion in Allergy and Clinical Immunology
Roos-Marijn BerbersHelen L Leavis

Abstract

With the emergence of the microbiota as a potential driver of host inflammation, the role of iIgA is becoming increasingly important. This review discusses the current evidence regarding the effects of clinical IgA deficiency on the microbiota, and the possible role of microbial dysbiosis in driving inflammation in PID patients. The gut microbiota has been investigated in selective IgA deficiency and common variable immunodeficiency, revealing an important role for IgA in maintaining gut microbiota homeostasis, with disparate effects of IgA on symbionts and pathobionts. Although IgA deficiency is associated with microbial translocation and systemic inflammation, this may be partially compensated by adequate IgG and IgM induction in IgA deficiency but not in common variable immunodeficiency. Therapeutic strategies aimed at correction of the microbiota mostly focus on fecal microbiota transplantation. Whether this may reduce systemic inflammation in PID is currently unknown. Clinical IgA deficiency is associated with microbial dysbiosis and systemic inflammation. The evidence for microbiota-targeted therapies in PID is scarce, but indicates that IgA-based therapies may be beneficial, and that fecal microbiota transplantation is w...Continue Reading

References

Oct 1, 1993·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J C BorleffsM Rozenberg-Arska
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Keiichiro SuzukiSidonia Fagarasan
Jul 19, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A FinocchiC Cancrini
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Jan 27, 2007·International Immunology·Leanne C SaitRichard A Strugnell
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Antonello GiovannettiFernando Aiuti
May 17, 2008·Nature Reviews. Immunology·Andrea Cerutti
Apr 4, 2009·Nature Reviews. Immunology·June L Round, Sarkis K Mazmanian
Feb 26, 2010·British Journal of Haematology·E Graham Davies, Adrian J Thrasher
Aug 14, 2010·Microbiology·Cecilia JernbergJanet K Jansson
Apr 15, 2011·The Journal of Clinical Investigation·Julia BenckertHedda Wardemann
Jun 21, 2011·Antiviral Therapy·Annick A J M van de VenJoris M van Montfrans
Oct 25, 2011·International Journal of Medical Microbiology : IJMM·Elisabet LönnermarkVanda Friman
Dec 20, 2011·Blood·Elena S ResnickCharlotte Cunningham-Rundles
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Feb 8, 2013·Journal of Clinical Immunology·G H JorgensenB R Ludviksson
Jul 23, 2013·Frontiers in Immunology·Blaise Corthésy
Mar 4, 2014·Journal of Clinical Immunology·Jonas F LudvigssonLennart Hammarström
Mar 19, 2014·Gut Microbes·Julie MirpuriFelix Yarovinsky
Sep 17, 2014·The Journal of Experimental Medicine·Matthieu PerreauGiuseppe Pantaleo
Jan 27, 2015·Cell Host & Microbe·Jason L KubinakJune L Round
Jul 5, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Noah W PalmRichard A Flavell
Feb 26, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Alexander KhorutsMichael J Sadowsky
Mar 2, 2016·The Journal of Experimental Medicine·Rosita RigoniBarbara Cassani
Aug 27, 2016·Nature Microbiology·Shinsaku OkaiReiko Shinkura
Nov 3, 2016·Gut Microbes·Rosita RigoniBarbara Cassani
Jun 3, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roberto L PatronRobert Orenstein
Oct 4, 2017·Science·Jeffrey J BunkerAlbert Bendelac
Dec 1, 2017·The Journal of Infectious Diseases·Jean de GunzburgAntoine Andremont
Dec 20, 2017·Nature Reviews. Rheumatology·Reinhold E SchmidtTorsten Witte
Feb 6, 2018·Diagnostic Microbiology and Infectious Disease·Keith A SaccoAvni Y Joshi
May 4, 2018·Science Translational Medicine·Jehane FadlallahGuy Gorochov

❮ Previous
Next ❯

Citations

Jul 9, 2020·Frontiers in Immunology·Roos-Marijn BerbersHelen L Leavis
Feb 13, 2021·International Journal of Molecular Sciences·Riccardo CastagnoliLuigi Daniele Notarangelo
Mar 7, 2021·International Journal of Molecular Sciences·Hao Wei, Ji-Yang Wang
May 11, 2021·Frontiers in Immunology·Yusuke Kinashi, Koji Hase
Oct 16, 2021·Current Opinion in Pediatrics·Maryam Ali Al-NesfVidya Mohamed-Ali

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriotherapy (ASM)

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Bacteriotherapy

Bacteriotherapy, also known as fecal transplantation, involves the transfer of stool from a healthy donor into the gastrointestinal tract for the purpose of treating recurrent C. difficile colitis. Here is the latest on bacteriotherapy.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Tadashi Ariga
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Venkata S AkshintalaMichael Goggins
© 2022 Meta ULC. All rights reserved