Immunoglobulin a as a serological marker for the (silent) circulation of poliovirus in an inactivated poliovirus-vaccinated population

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
T HerremansM P Koopmans

Abstract

Poliovirus-specific immunoglobulin A (IgA) is detected after infection with wild-type virus or vaccination with live attenuated oral poliovirus (OPV) but not after vaccination with inactivated poliovirus (IPV). We examined whether the presence of IgA in serum can be used as a marker for poliovirus circulation in IPV-vaccinated populations in The Netherlands. In seronegative persons challenged with OPV, the sensitivity of this marker was 76%-86%. Results from a serosurvey showed a high seroprevalence (63%-73%) of IgA in the population born before vaccination was introduced in The Netherlands, which reflects natural exposure. The start of the vaccination program in 1957 corresponded to a reduction in the IgA seroprevalence in both vaccinated (2.1%-4.5%) and nonvaccinated groups (8.3%-11.7%). The presence of IgA-positive persons in the population could largely be explained by the occurrence of episodes of proven poliovirus circulation. We propose to use the detection of poliovirus-specific IgA as a tool to monitor virus circulation in IPV-vaccinated and nonvaccinated populations, to aid the poliovirus eradication process.

References

Jan 1, 1991·The Journal of Infectious Diseases·I M OnoratoR H Bernier
May 1, 1984·Reviews of Infectious Diseases·H Bijkerk
Sep 25, 1997·Clinical and Diagnostic Laboratory Immunology·M M HerremansM P Koopmans
Dec 10, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T HerremansA M van Loon
Feb 7, 2001·American Journal of Epidemiology·M A Conyn-Van SpaendonckT van Loon

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Citations

Feb 19, 2008·The Journal of Infectious Diseases·Anne-Marie BuismanTjeerd G Kimman
Jan 25, 2014·The Journal of Infectious Diseases·Peter F WrightRoland W Sutter
Aug 26, 2014·Science·Hamid JafariR Bruce Aylward
Jul 15, 2015·Expert Review of Vaccines·Edward Pk ParkerNicholas C Grassly
Sep 10, 2002·The Journal of Infection·Subhash C Arya
Sep 1, 2017·Human Vaccines & Immunotherapeutics·James A ChurchAndrew J Prendergast
Aug 26, 2003·Journal of Medical Virology·Elena SamoilovichTapani Hovi
Dec 24, 2018·Transactions of the Royal Society of Tropical Medicine and Hygiene·James A ChurchAndrew J Prendergast

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