Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis

American Journal of Obstetrics and Gynecology
Sabina CauciFranco Quadrifoglio

Abstract

The aim of this study was to investigate the correlation between the immunoglobulin A immune response to Gardnerella vaginalis hemolysin and sialidase activity in vaginal fluids from patients with bacterial vaginosis. Nonpregnant women who were examined at a gynecologic clinic, in an age range of 18 to 62 years, were enrolled. The study population comprised 131 healthy volunteers, 32 women with bacterial vaginosis that was positive for immunoglobulin A to Gardnerella vaginalis hemolysin, 40 women with bacterial vaginosis that was negative for immunoglobulin A to Gardnerella vaginalis hemolysin, and 19 women with Candida vaginitis. Bacterial vaginosis was diagnosed by clinical criteria and Gram stain. Sialidase activity was present in 75% (54/72) of patients with bacterial vaginosis. Women having bacterial vaginosis and lacking a specific immunoglobulin A response had a significantly higher level of sialidase activity than patients who had an immune response against Gardnerella vaginalis hemolysin. Sialidase activity was detected in 87% (35/40) of the former subgroup of patients with bacterial vaginosis and in 59% (19/32) of women of the latter subgroup. No sialidase activity was measured in patients with candidiasis. Specificit...Continue Reading

References

Jun 29, 1978·The New England Journal of Medicine·T A PheiferK K Holmes
May 1, 1979·The Journal of Clinical Investigation·K C ChenK K Holmes
Oct 13, 1988·The New England Journal of Medicine·S L HillierD A Eschenbach
Sep 11, 1980·The New England Journal of Medicine·C A SpiegelK K Holmes
Sep 1, 1993·Molecular Microbiology·S CauciG Menestrina
Apr 1, 1994·American Journal of Obstetrics and Gynecology·D E SoperD Johnson
Nov 21, 1993·Biochimica Et Biophysica Acta·S CauciG Menestrina
Aug 1, 1993·American Journal of Obstetrics and Gynecology·D A Eschenbach
Aug 1, 1993·American Journal of Obstetrics and Gynecology·R S Gibbs
Aug 1, 1996·Trends in Biochemical Sciences·C G Gahmberg, M Tolvanen
Dec 1, 1996·American Journal of Obstetrics and Gynecology·S CauciF Quadrifoglio
Dec 1, 1996·Current Opinion in Structural Biology·G Taylor

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Citations

May 8, 2003·Journal of Clinical Microbiology·Linda MyziukStephen C Johnson
Dec 7, 2007·Journal of Clinical Microbiology·Philippe R S Lagacé-WiensKathryn Bernard
Jul 14, 2009·Journal of Perinatal Medicine·Mirjana A Bogavac, Snezana Brkić
Nov 13, 2004·Current Infectious Disease Reports·Sabina Cauci
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Angelo FiorilliMassimo Milani
Jan 22, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·R F LamontR Romero
Feb 15, 2014·Infectious Diseases in Obstetrics and Gynecology·Purnima MadhivananJeffrey D Klausner
Mar 30, 2011·American Journal of Obstetrics and Gynecology·Guido Lopes dos Santos SantiagoMario Vaneechoutte
Nov 9, 2010·American Journal of Obstetrics and Gynecology·Sabina Cauci, Jennifer Flatow Culhane
Feb 8, 2005·American Journal of Obstetrics and Gynecology·Sabina CauciSecondo Guaschino
Apr 22, 2015·Current Infectious Disease Reports·Gilbert G G DondersGert Bellen
Feb 5, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C MarconiM G Silva
Aug 25, 2001·Paediatric and Perinatal Epidemiology·C HolzmanUNKNOWN Prematurity Study Group
Jun 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Rodney K EdwardsPatrick Duff
Dec 29, 2000·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·P A Mårdh
Jun 8, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J A SimoesM C M Dantas
Jul 29, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·D M PaternosterA Ambrosini
May 17, 2001·Sexually Transmitted Diseases·E H KoumansUNKNOWN CDC Bacterial Vaginosis Working Group
Jul 17, 2004·Gynecologic and Obstetric Investigation·Cléber Sérgio da SilvaEddie Fernando Candido Murta
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ferdinand C O LosAdam J Ratner
Feb 23, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·U ForsumI Mattsby-Baltzer
Dec 24, 2005·Current Opinion in Infectious Diseases·Gilbert G G Donders
Aug 10, 2017·Journal of Medical Microbiology·Carolina Sanitá Tafner FerreiraCamila Marconi
May 29, 2020·Applied Microbiology and Biotechnology·Karen Cortés-SarabiaAmalia Vences-Velázquez
Nov 8, 2020·International Journal of Molecular Sciences·Guillaume LacroixJean-Luc Desseyn
Feb 23, 2021·ACS Pharmacology & Translational Science·Cynthia Rodríguez-NavaEden Morales-Narváez

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