Immunoglobulin A1 protease: a new therapeutic candidate for immunoglobulin A nephropathy

Nephrology
Lin-Shen XieJun Ming Fan

Abstract

Immunoglobulin A nephropathy (IgAN), characterized by predominant or exclusive deposition of IgA1 in glomerular mesangium, is the most common primary glomerulonephritis worldwide. At present, the treatment is always limited due to the incomplete understanding of the pathogenesis of IgAN. Mesangial deposited IgA1 is the common final pathway leading to glomerulonephritis and renal injury. IgA1 protease, a proteolytic enzyme with strict substrate specificity for human IgA1, may be an effective therapeutic candidate for IgAN by removing the mesangial deposited IgA1.

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Citations

Jan 28, 2014·Biochemical and Biophysical Research Communications·Man YangJun-ming Fan
Jun 3, 2015·Nephrology·See Cheng YeoJonathan Barratt
Jun 22, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rosanna Coppo

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