Immunoglobulin-bearing blood leucocytes in the Pacific hagfish

Developmental and Comparative Immunology
R L Raison, W H Hildemann

Abstract

The occurrence of immunoglobulin (Ig) bearing leucocytes in the blood of the Pacific hagfish, Eptatretus stoutii , was examined using a murine monoclonal antibody (45.3) and a rabbit antiserum specific for hagfish serum Ig. Binding of antibody 45.3 to hagfish leucocytes assessed by radioimmunoassay was inhibited by preincubation of antibody with purified serum Ig thus verifying the presence of cell surface Ig cross reactive with serum Ig. The monoclonal antibody identified approximately 65% of blood leucocytes as Ig+ve while the rabbit antiserum indicated 81% Ig+ve cells. Both antibody preparations failed to react specifically with cells from mouse, horned shark, tunicate or sea star; this indicates the distinctive nature of hagfish Ig. The high percentage of blood cells bearing surface Ig in the hagfish raises the possibility that lymphocyte divergence to separate B and T pathways may not have occurred in this most primitive vertebrate. Alternatively, an Ig-like specificity characteristic of both "T" and "B" lymphocytes may have been detected. In any event, a subset of Ig negative leucocytes is evident in hagfish.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R L RaisonW H Hildemann
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Citations

Jan 1, 1986·Developmental and Comparative Immunology·P GilbertsonR L Raison
May 28, 2013·Developmental and Comparative Immunology·Giuseppe Scapigliati
May 14, 2005·Fish & Shellfish Immunology·J H W M RomboutG Scapigliati
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·P J HanleyR L Raison
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Zeev PancerMax D Cooper
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·D J LairdI L Weissman
Apr 1, 1987·Immunology and Cell Biology·R L RaisonJ Wotherspoon

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