Immunoglobulin C-gene expression. I. The commitment to IgG subclass of secretory cells is determined by the quality of the nonspecific stimuli

European Journal of Immunology
C Martinez-AlonsoA A Augustin

Abstract

Polyclonal stimulation of normal splenic B lymphocytes with either lipopolysaccharide (LPS) or helper T lymphocytes specific for B cell surface antigens results in the selective expression of IgG subclasses by the secretory cells: in addition to IgM-secreting plaque-forming cells (PFC), thymus-independent stimulation leads to the development of IgG2 and IgG3 PFC, while helper cell-dependent activation leads to IgG1 and IgG2 PFC. This cannot be solely explained by selective stimulation of distinct B cell subpopulations, because purified LPS-reactive blasts if restimulated by helper cells switch to IgG1 while if maintained with LPS switch to IgG3. The simultaneous stimulation of splenic B cells with LPS and helper cells results in additive IgM and IgG2 responses, but in the selective suppression of IgG3 PFC with a concomitant synergic enhancement of IgG1 responses. These results are interpreted to indicate that the expression of IgG C genes in proliferating B lymphocytes is directed by the quality of nonspecific stimuli.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Honjo, T Kataoka
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·J AnderssonT Watanabe
Jun 1, 1978·The Journal of Experimental Medicine·J AnderssonF Melchers
Mar 1, 1979·The Journal of Experimental Medicine·J AnderssonF Melchers
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·B PernisA L Luzzati
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Jan 1, 1975·Scandinavian Journal of Immunology·F MelchersJ Andersson
Jan 1, 1975·Advances in Immunology·A Coutinho, G Möller
Mar 1, 1980·The Journal of Experimental Medicine·A A Augustin, A Coutinho
Jan 1, 1980·The Journal of Experimental Medicine·M H SchreierF Melchers

❮ Previous
Next ❯

Citations

Mar 1, 1982·The Journal of Experimental Medicine·P C IsaksonP H Krammer
Jul 1, 1982·The Journal of Experimental Medicine·D PrimiP A Cazenave
Nov 1, 1983·The Journal of Experimental Medicine·F IvarsA Coutinho
Jun 1, 1990·Scandinavian Journal of Immunology·E E Karagouni, L Hadjipetrou-Kourounakis
Nov 1, 1981·Acta paediatrica Scandinavica·U AnderssonS Britton
Sep 1, 1981·Immunology Today·G Möller
Apr 1, 1989·Clinical Immunology and Immunopathology·P AucouturierJ L Preud'Homme
Jan 1, 1982·Immunological Reviews·A CoutinhoS Pettersson
Jan 1, 1982·Immunological Reviews·Y J Rosenberg
Jan 1, 1982·Immunological Reviews·E SeverinsonC Fernandez
Jan 1, 1982·Immunological Reviews·J P McKearnJ M Davie
Feb 1, 1988·Immunological Reviews·P SiderasT Honjo
Apr 1, 1984·Immunological Reviews·S Bergstedt-LindqvistE Severinson
Apr 1, 1984·Immunological Reviews·A CoutinhoC Martinez
Apr 1, 1984·Immunological Reviews·S Al-BalaghiE Möller
Jun 30, 1983·Annals of the New York Academy of Sciences·M F Kagnoff
Aug 1, 1985·European Journal of Immunology·I SeppäläO Mäkelä
Oct 1, 1985·European Journal of Immunology·M BjörklundA Coutinho
Feb 1, 1986·European Journal of Immunology· Lê thi Bich-Thuy, J P Revillard
Oct 1, 1981·European Journal of Immunology·R BennerH Hooijkaas
Mar 1, 1984·Scandinavian Journal of Immunology·L Hadjipetrou-Kourounakis, E Möller
Jun 1, 1985·European Journal of Immunology·P SiderasE Severinson
Dec 1, 1988·European Journal of Immunology·C MartinezP Pereira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.