Abstract
The IGHG (ImmunoGlobulin constant Heavy G chain) genes are situated close to the IGHE gene on chromosome 14q32, 5'mu, delta, gamma3, gamma1, alpha1, gamma2, gamma4, epsilon, alpha2, 3', in linkage disequilibrium. The polymorphism of gamma3, gamma1 and gamma2 genes, is investigated as alternative allotypes. They are inherited in a Mendelian fashion and are expressed randomly in allelic exclusion. The alternative and functionally different gamma3, gamma1 and gamma2 gene variants, are found in four IGHG haplotypes, coding 4 B-cell variants: IGHG*bfn (=B1-cells), IGHG*bf-n (=B2-cells), IGHG*gan (=B3-cells) and IGHG*ga-n (=B4-cells). The dominance of the IGHG2*n allele from the IGHG*bfn haplotype (=B1-cells) has been shown in repeated investigations, namely in patients with asthma and allergy with increased serum levels of IgE > 600 ku/l and more often so in those with IgE > 1,000 ku/l or IgG4>1 g/l, in childhood asthma patients with mean level of IgE = 1,762 ku/l and in allergen exposed individuals developing laboratory animal allergy. In children with non-atopy and mean IgE level = 9.5 ku/l there is instead a dominance of the alternative allotypes from the IGHG*ga-n (=B4-cells) with IGHG2*-n alleles. In a case-control study allerg...Continue Reading
References
Jan 27, 1979·Lancet·J P PandeyJ C Parke
Feb 1, 1990·Scandinavian Journal of Immunology·V A Oxelius
Jan 1, 1990·International Archives of Allergy and Applied Immunology·V A Oxelius
Jan 1, 1990·International Archives of Allergy and Applied Immunology·V A Oxelius
Jun 10, 1989·Lancet·W O CooksonJ M Hopkin
Sep 1, 1987·Primary Care·A S Paller
Jun 1, 1985·The Journal of Clinical Investigation·D M AmbrosinoG R Siber
Dec 24, 1981·The New England Journal of Medicine·D G MarshW B Bias
Feb 1, 1982·Human Immunology·L LegrandJ Dausset
Sep 23, 1995·BMJ : British Medical Journal·M R HillW O Cookson
Feb 6, 1993·Lancet·A J SandfordW O Cookson
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius, A M Carlsson
Feb 1, 1993·Scandinavian Journal of Immunology·V A Oxelius
Jan 1, 1993·International Archives of Allergy and Immunology·V A OxeliusS Husby
May 1, 1996·International Archives of Allergy and Immunology·V A OxeliusB Löw
Aug 1, 1996·Journal of Medical Genetics·A J Walley, W O Cookson
Nov 1, 1996·Clinical and Experimental Immunology·V A Oxelius, M M Eibl
Mar 31, 1998·BMJ : British Medical Journal·D Jarvis, P Burney
Apr 8, 1998·International Archives of Allergy and Immunology·V A OxeliusM Aurivillius
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Apr 29, 1999·Scandinavian Journal of Immunology·V A Oxelius
Oct 16, 1999·Scandinavian Journal of Immunology·V A OxeliusK Musil
Dec 10, 1999·Nature·S T Holgate
Dec 10, 1999·Nature·W Cookson
Nov 30, 2000·Allergy·V A Oxelius
Feb 24, 2001·Genes and Immunity·T C van der Pouw KraanJ S van der Zee
Nov 13, 2001·Human Immunology·E NoguchiT Arinami
Dec 21, 2002·Immunological Reviews·William Cookson
Sep 11, 2004·Journal of Clinical Immunology·M Hahn-ZoricL A Hanson
Aug 12, 2005·Acta Paediatrica·Magnus AurivilliusVivi-Anne Oxelius
Dec 21, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V-A OxeliusB Björkstén
Citations
May 9, 2012·Cellular and Molecular Life Sciences : CMLS·Peter A Doris
Jul 3, 2010·American Journal of Respiratory Cell and Molecular Biology·YuXiu C XiaGraham A Mackay
Jan 1, 2010·Annals of Vascular Diseases·Satomi Kasashima, Yoh Zen
Jun 22, 2012·Annals of Medicine·Michael C Braun, Peter A Doris
Jan 16, 2010·MAbs·Roy Jefferis, Marie-Paule Lefranc
Dec 3, 2010·Current Opinion in Rheumatology·Satomi Kasashima, Yoh Zen
May 11, 2012·International Archives of Allergy and Immunology·Vivi-Anne Oxelius
Sep 24, 2019·Antibodies·Steven W de TaeyeGestur Vidarsson
Jan 21, 2020·American Journal of Physical Anthropology·Domenico FrezzaAndrea Novelletto
May 22, 2020·Frontiers in Immunology·Steven W de TaeyeGestur Vidarsson
Mar 1, 2020·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yangyang FengWanli Liu
Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology