Immunoglobulin constant heavy G subclass chain genes in asthma and allergy.

Immunologic Research
Vivi-Anne Oxelius

Abstract

The IGHG (ImmunoGlobulin constant Heavy G chain) genes are situated close to the IGHE gene on chromosome 14q32, 5'mu, delta, gamma3, gamma1, alpha1, gamma2, gamma4, epsilon, alpha2, 3', in linkage disequilibrium. The polymorphism of gamma3, gamma1 and gamma2 genes, is investigated as alternative allotypes. They are inherited in a Mendelian fashion and are expressed randomly in allelic exclusion. The alternative and functionally different gamma3, gamma1 and gamma2 gene variants, are found in four IGHG haplotypes, coding 4 B-cell variants: IGHG*bfn (=B1-cells), IGHG*bf-n (=B2-cells), IGHG*gan (=B3-cells) and IGHG*ga-n (=B4-cells). The dominance of the IGHG2*n allele from the IGHG*bfn haplotype (=B1-cells) has been shown in repeated investigations, namely in patients with asthma and allergy with increased serum levels of IgE > 600 ku/l and more often so in those with IgE > 1,000 ku/l or IgG4>1 g/l, in childhood asthma patients with mean level of IgE = 1,762 ku/l and in allergen exposed individuals developing laboratory animal allergy. In children with non-atopy and mean IgE level = 9.5 ku/l there is instead a dominance of the alternative allotypes from the IGHG*ga-n (=B4-cells) with IGHG2*-n alleles. In a case-control study allerg...Continue Reading

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Citations

May 9, 2012·Cellular and Molecular Life Sciences : CMLS·Peter A Doris
Jul 3, 2010·American Journal of Respiratory Cell and Molecular Biology·YuXiu C XiaGraham A Mackay
Jan 1, 2010·Annals of Vascular Diseases·Satomi Kasashima, Yoh Zen
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Sep 5, 2008·Current Opinion in Allergy and Clinical Immunology

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