PMID: 8446604Mar 1, 1993Paper

Immunoglobulin D-deficient mice can mount normal immune responses to thymus-independent and -dependent antigens

Proceedings of the National Academy of Sciences of the United States of America
L NitschkeM C Lamers

Abstract

To examine the in vivo function of IgD we generated mice deficient for IgD by gene targeting. The IgD-mice show a reduced B-cell compartment with 30-50% less B cells in the spleen and lymph nodes but show a normal pre-B-cell compartment. The surface-IgD- B cells express two to three times more surface IgM than B cells of control animals. Serum concentrations of the immunoglobulin isotypes of IgD- mice are almost normal, indicating that surface-IgD expression is not necessary for class switching of B cells. Immunization experiments showed that IgD- mice could respond well to thymus-dependent and -independent antigens. After immunization normal germinal centers developed in the IgD- mice. These data suggest that IgD is not necessary for the induction of immune responses but may be important in homeostasis of cells in the B-cell compartment.

References

Dec 1, 1977·The Journal of Experimental Medicine·I M ZitronW E Paul
Jan 1, 1977·Immunological Reviews·E S Vitetta, J W Uhr
May 1, 1978·European Journal of Immunology·J E LaytonG J Nossal
Apr 1, 1978·The Journal of Experimental Medicine·S J BlackL A Herzenberg
Nov 1, 1985·The Journal of Experimental Medicine·B G Froscher, N R Klinman
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R TischN Hozumi
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E Alés-MartínezD W Scott
May 1, 1980·The Journal of Experimental Medicine·L A HerzenbergL A Herzenberg
Jan 1, 1982·Annals of the New York Academy of Sciences·R R HardyL A Herzenberg
Jan 1, 1993·European Journal of Immunology·R CarsettiM C Lamers

❮ Previous
Next ❯

Citations

Jul 27, 1994·Molecular and Cellular Biochemistry·B S Shastry
Dec 1, 1993·Current Opinion in Immunology·D Nemazee
Apr 1, 1995·Current Opinion in Immunology·F MelchersJ Andersson
Dec 1, 1993·Current Opinion in Biotechnology·P Mombaerts
Aug 10, 2000·Molecular Immunology·W W Schamel, M Reth
Apr 3, 2001·Molecular Immunology·J L Preud'hommeE Lelièvre
Feb 1, 1997·Current Biology : CB·L NitschkeM C Lamers
Aug 14, 1999·Scandinavian Journal of Immunology·I HordvikB Krossøy
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·S M SingerH O McDevitt
Mar 7, 2000·Clinical and Diagnostic Laboratory Immunology·A O Vladutiu
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M WilsonG W Warr
Oct 2, 2003·Expert Opinion on Biological Therapy·L H Stockwin, S Holmes
Mar 1, 2011·Current Opinion in Immunology·Kang Chen, Andrea Cerutti
Mar 19, 2011·Developmental and Comparative Immunology·Eva-Stina EdholmMelanie Wilson
Aug 24, 2010·Immunological Reviews·Kang Chen, Andrea Cerutti
May 23, 2006·Journal of Immunological Methods·David E MosedaleDavid J Grainger
Dec 1, 1996·The Journal of Allergy and Clinical Immunology·M MayumiK Katamura
Oct 13, 2005·Immunology Letters·Roland GeisbergerGernot Achatz
Jul 1, 1995·Current Biology : CB·E P BrandonG S McKnight
Apr 8, 2015·Nature Immunology·Rudolf ÜbelhartHassan Jumaa
Nov 5, 1999·International Immunology·I Levan-PetitJ C Lecron
Mar 3, 2004·European Journal of Immunology·Shuhua HanBiao Zheng
Nov 25, 2003·Immunology·Roland GeisbergerGernot Achatz
May 8, 2018·European Journal of Immunology·Cindy GutzeitAndrea Cerutti
Aug 26, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jana NechvatalovaMenno C van Zelm
Aug 10, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Shoya YasudaJi-Yang Wang
Oct 12, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Ting ChenJohn T Kung
Nov 11, 2016·Nature Communications·Zahra SabouriChristopher C Goodnow
Aug 10, 2006·Immunology·Roland GeisbergerGernot Achatz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.