PMID: 9360257Jan 1, 1997

Immunoglobulin deficiencies and impaired immune response to polysaccharide antigens in adult patients with recurrent community-acquired pneumonia

Scandinavian Journal of Infectious Diseases
K EkdahlC Svanborg

Abstract

The frequency of humoral immunodeficiencies was analysed in 39 patients with a history of recurrent (> or = 3) episodes of community-acquired pneumonia. Total immunoglobulin levels and/or IgG subclass levels were low in 14 patients (36%), including eight patients with IgG or IgG2 deficiency. The specific antibody activity to pneumococcal capsular polysaccharides (serotypes 3, 6A, 19F, and 23F) and to phosphorylcholine was low in the IgG/IgG2-deficient patients compared to 36 healthy controls, and they also responded poorly to vaccination with a 23-valent pneumococcal capsular polysaccharide vaccine. The remaining 25 patients, with normal immunoglobulin and IgG subclass levels, had specific anti-pneumococcal antibody levels comparable to the healthy controls, and all but 3 responded to vaccination. We conclude that immunoglobulin deficiencies and the inability to respond to polysaccharide antigens are common risk factors for recurrent pneumonia in adult patients. Immunoglobulin levels (including IgG subclasses) and antibody response to polysaccharide antigens should be investigated in these patients.

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Citations

Dec 15, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Joshua A CohnJohn R Cohn
Aug 9, 2011·American Journal of Rhinology & Allergy·Tara F CarrAnju T Peters
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Sep 28, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·E SarmientoJ Carbone
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Apr 16, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Lais FonsecaAry Gadelha
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esther M YooSherie L Morrison
Nov 13, 2003·Current Opinion in Allergy and Clinical Immunology·Capucine PicardJean-Laurent Casanova
Jun 8, 2017·Frontiers in Immunology·Elena PerezMark Ballow

Related Concepts

Antibodies, Bacterial
Antigens, Bacterial
Bacterial Vaccines
Dysgammaglobulinemia
Polyglobin
Immunoglobulins
Phosphorylcholine
Streptococcal Pneumonia
Polysaccharides, Bacterial
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