Immunoglobulin E elevation in Plasmodium chabaudi malaria.

Infection and Immunity
H HelmbyP Perlmann

Abstract

In order to investigate the mechanism of immunoglobulin E (IgE) elevation in malaria we studies mice infected with asexual blood stages of the rodent malaria parasite Plasmodium chabaudi chabaudi for total IgE and IgE antimalarial antibodies. Multiply infected mice had elevated levels of total as well as malaria-specific IgE in their sera. Sera taken from mice 3 weeks after one infection with P. chabaudi showed no IgE elevation, indicated that prolonged or repeated exposure to the parasite is necessary for the induction of an IgE response, which also is induced independently of previous or simultaneous infection with other pathogens such as helminths.

References

Jan 1, 1992·Annual Review of Immunology·A Sher, R L Coffman
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Troye-BlombergP Perlmann
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·R S Desowitz
Oct 1, 1994·European Journal of Immunology·T von der WeidJ Langhorne
Jun 25, 1993·Science·A W Taylor-RobinsonF Y Liew

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