Immunoglobulin E-mediated increase in vascular permeability correlates with eosinophilic inflammation

The American Review of Respiratory Disease
D S CollinsS P Peters

Abstract

An increase in bronchovascular permeability is thought to play an important role in the pathogenesis of allergic asthma. We sought to determine whether the increase in permeability observed 24 h after segmental antigen challenge in ragweed-allergic human volunteers was associated with the infiltration and degranulation of a specific cell type. A 20,000-fold range of antigen concentrations was used to alter the number and type of inflammatory cells recruited to the lung by challenge. Although large numbers of inflammatory cells were recruited to lung air spaces over a large range of antigen concentrations, significant numbers of eosinophils (731.3 +/- 232.9 x 10(3)/ml) were recruited only when the concentration of antigen used for segmental challenge was > or = 100-fold higher than the concentration needed to produce an 8 to 10 mm wheal 20 min after intradermal skin testing. In addition, large increases in bronchoalveolar lavage (BAL) albumin concentration (636.3 +/- 170.5 micrograms/ml) were observed only in this same group of subjects. The correlation coefficient between the logarithms of the BAL eosinophil concentration and albumin concentration was +0.82 (p < 0.001), and between eosinophil-derived neurotoxin and albumin it w...Continue Reading

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Citations

Feb 1, 1994·Current Opinion in Immunology·P F Weller
Apr 14, 2005·Cytokine·A B Paoliello-PaschoalatoF Q Cunha
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Jul 14, 2017·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J WangM D Howell

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