PMID: 9440543Jan 24, 1998Paper

Immunoglobulin E production in mice by means of contact sensitization with a simple chemical, hapten

The Journal of Allergy and Clinical Immunology
Hiroichi NagaiK Kawada

Abstract

Production of IgE caused by repeated topical application of 2,4-dinitrofluorobenzene (DNFB) to the ears of BALB/c mice was investigated. Ear thickness increased in proportion to the number of applications. Eczematous changes of the skin included marked infiltration of neutrophils, eosinophils, and monocytes and hypertrophy of the epidermis. Ear thickness due to inflammation reached a maximum 24 hours after the second, third, fourth, and fifth applications. The strong expression of interferon-gamma and IL-2 messenger RNA (mRNA) in the skin lesions indicated the participation of Th1 type helper T cells in the delayed-type hypersensitivity reaction. After the fifth application, the mice showed an immediate cutaneous reaction in addition to the delayed-type hypersensitivity reaction. The immediate reaction appeared within 1 hour of application. Hapten-specific IgE also was detected in serum from the mice, and the expression of germline and productive Cepsilon mRNA was detected in cervical lymph nodes, whereas productive Cepsilon mRNA was detected in the spleen. These results indicate that five topical applications of DNFB to the ear produce local eczematous dermatitis and increase serum hapten-specific IgE level in mice. Eczematous...Continue Reading

Citations

Dec 23, 2003·Toxicology Letters·Harunobu NakamuraHiroichi Takeuchi
Jan 3, 2001·European Journal of Pharmacology·T KunikataM Kurimoto
Jul 1, 2002·Environmental Toxicology and Pharmacology·Anneke H van HouwelingenFrans P Nijkamp
May 9, 2003·Biological & Pharmaceutical Bulletin·Yoshifumi UedaHiroichi Nagai
Apr 15, 2008·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Naoki InagakiHiroichi Nagai
Oct 7, 2010·Journal of Nutritional Science and Vitaminology·Reiko FujiwaraKei Sonoyama
Feb 1, 2002·Biochemical and Biophysical Research Communications·Yoshiaki TomimoriYoshiaki Fukuda
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Apr 6, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Naoki Inagaki, Hiroichi Nagai

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