PMID: 2508087Oct 1, 1989Paper

Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene

Proceedings of the National Academy of Sciences of the United States of America
G G HermansonR Wall

Abstract

B29 is a B-cell-specific member of the immunoglobulin gene superfamily that is expressed throughout B-cell development beginning with the earliest precursor B cells undergoing immunoglobulin heavy-chain gene segment rearrangements. We have analyzed the region upstream of the B29 gene to identify DNA sequences involved in transcriptional regulation of this gene. The B29 gene lacks a TATA box and transcription is initiated at multiple sites. The B29 gene sequence 5' of these transcription start sites contains six promoter and enhancer motifs known to control immunoglobulin gene transcription. The most notable is a perfect octamer (5'-ATTTGCAT-3'), which binds the Oct-2 B-cell-specific transcription factor and thereby can account for the tissue-specific expression of this gene.

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Citations

Nov 20, 2002·Biochemical and Biophysical Research Communications·Shinji TakechiTatsuo Nakayama
Sep 23, 2000·Molecular Immunology·C S MaloneR Wall
May 1, 1997·Veterinary Immunology and Immunopathology·H Y YounA Hasegawa
Oct 3, 2002·Biochimica Et Biophysica Acta·Shinji TakechiTatsuo Nakayama
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K S CampbellJ C Cambier
Jan 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·K IshiharaP W Kincade
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S A Omori, R Wall
Apr 4, 2006·Nucleic Acids Research·Cornelia Brunner, Thomas Wirth
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·C S MaloneR Wall
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Melinda S GordonRandolph Wall
Feb 22, 2002·European Journal of Biochemistry·Ayano KomatsuMasao Ono
Jan 20, 1997·The Journal of Experimental Medicine·M D ScharffN S Green
Jan 20, 1997·The Journal of Experimental Medicine·K Tumas-Brundage, T Manser
Jul 1, 1992·Baillière's Clinical Haematology·P W Kincade
Aug 24, 2006·British Journal of Haematology·E SakhiniaG Brady
Sep 30, 1992·Biochemical and Biophysical Research Communications·Z H LiJ B Bolen
Nov 18, 2006·European Journal of Immunology·Christian VettermannHans-Martin Jäck
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Jun 1, 1994·European Journal of Immunology·C RadaC Milstein
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cindy Sue Malone, Randolph Wall
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Jun 1, 1992·Molecular and Cellular Biology·Z KozmikM Busslinger
Jul 1, 1992·Molecular and Cellular Biology·A AnnweilerT Wirth

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