PMID: 9661812Jul 14, 1998Paper

Immunoglobulin G abnormalities in HIV-1 infected individuals with lymphoma

Immunotechnology : an International Journal of Immunological Engineering
P LundholmB Wahren

Abstract

Polyclonal B-cell activation precedes the occurrence of malignant B-cell clones. Several recent reports suggest a perturbed cytokine regulation in HIV-related lymphomagenesis and Epstein-Barr virus (EBV) involvement in approximately half of the cases with generalized lymphoma. We investigated whether altered immunoglobulin properties would be detected by fine analysis of the immunoglobulin G (IgG) subclass patterns against HIV and EBV epitopes. HIV-1 infected patients in early stage, late stage and with lymphoma were analyzed by ELISA for anti HIV and EBV IgG class and subclass antibodies. Avidity and affinity of the antibodies were studied. The lymphoma patients were also studied by PCR for EBV DNA in serum. The total IgG reactivity to several HIV antigens was similar in the three patient groups. However, lymphoma patients had a more restricted subclass pattern with significantly lower IgG1 and IgG3 anti gp120 titers compared to other HIV-infected patients but good and persistent total IgG and IgG1 (excluding the gp120 antigen) reactivities in contradiction to their low CD4 counts. IgG4 reactivity was sparse, detectable to significant levels in the symptomatic group only. The observed relative affinity of the HIV-specific IgG ...Continue Reading

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P A BrolidenK Broliden
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T J PalkerB F Haynes
Feb 1, 1988·AIDS Research and Human Retroviruses·J KhalifeA Capron
May 1, 1988·Journal of Clinical Immunology·K Hedman, I Seppälä
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·J R MüllerC S Rabkin
Aug 1, 1994·AIDS·B G HerndierM S McGrath
Feb 1, 1994·The Journal of Experimental Medicine·F BrièreJ Banchereau
Aug 1, 1993·The Journal of Experimental Medicine·I MiyazakiH M Dosch
Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·L M BarkholtA Lindé
Feb 14, 2006·Journal of Virology·Jing YuanElliott Kieff

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.