PMID: 9428109Jan 15, 1998Paper

Immunoglobulin G and F(ab')2 polyvalent antivenoms do not differ in their ability to neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom

Toxicon : Official Journal of the International Society on Toxinology
G LeónJ M Gutiérrez

Abstract

The ability of whole immunoglobulin G (IgG) and F(ab')2 polyvalent (Crotalinae) antivenoms to neutralize the hemorrhagic, edema-forming and myotoxic activities of Bothrops asper venom was studied. Both antivenoms were adjusted to the same neutralizing potency against lethal and hemorrhagic activities in experiments where venom and antivenoms were incubated before injection. Thus, in these experimental conditions, differences in the neutralizing ability in experiments involving independent injection of venom and antivenoms would depend mainly on the different pharmacokinetic profiles of whole IgG and F(ab')2 antivenoms. Experiments involving local injection of venom followed by intravenous administration of antivenom at either 0, 15 or 30 min after envenomation did not reveal any significant difference between whole IgG and F(ab')2 products concerning neutralization of hemorrhage, edema and myonecrosis induced by B. asper venom. The three effects were neutralized by antivenoms only to a partial extent and neutralization decreased as the time-lapse between envenomation and antivenom administration increased. Moreover, with the exception of one time-interval, no significant differences in the neutralization of hemorrhage were obse...Continue Reading

References

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Citations

Jun 20, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Guillermo LeónJosé María Gutiérrez
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Fernando ChavesJosé María Gutiérrez
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·Carolina BattellinoSandra H P Farsky
Apr 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·R D G TheakstonE Griffiths
Oct 8, 2003·Toxicon : Official Journal of the International Society on Toxinology·Ana M BarbosaJosé C Cogo
Oct 29, 1998·Toxicon : Official Journal of the International Society on Toxinology·J M GutiérrezF Chaves
Nov 16, 2013·PloS One·Keity Souza SantosMário Sérgio Palma
Jul 9, 2003·Clinical Pharmacokinetics·José María GutiérrezBruno Lomonte
Jul 20, 2010·Biologicals : Journal of the International Association of Biological Standardization·Gabriela SolanoGuillermo León
Aug 13, 2009·Toxicon : Official Journal of the International Society on Toxinology·Alvaro SeguraGuillermo León
Dec 7, 2007·Toxicon : Official Journal of the International Society on Toxinology·Karol AzofeifaBruno Lomonte
Jun 17, 2003·Journal of Toxicology. Clinical Toxicology·David G Lalloo, R David G Theakston
Sep 6, 2015·Toxicon : Official Journal of the International Society on Toxinology·Amanda J WitsilSangeeta Rao
Jun 12, 2016·Toxicon : Official Journal of the International Society on Toxinology·Mario RivelJosé María Gutiérrez
Nov 9, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G PicoloY Cury
Oct 26, 2005·Cell Biochemistry and Function·K Kemparaju, K S Girish
Mar 28, 2009·Toxicon : Official Journal of the International Society on Toxinology·Bruno LomonteVitelbina Núñez

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