Immunoglobulin G antibodies against Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans in cardiovascular disease and periodontitis

Journal of Oral Microbiology
Christian DamgaardPalle Holmstrup

Abstract

Objectives: The aim was to elucidate whether levels of circulating antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis correlate to loss of attachment, as a marker for periodontitis and cardiovascular disease (CVD). Design: Sera were collected from 576 participants of the Danish Health Examination Survey (DANHES). Immunoglobulin G antibodies against lipopolysaccharide (LPS) and protein antigens from the a, b and c serotypes of A. actinomycetemcomitans and P. gingivalis were quantified by titration in ELISA plates coated with a mixture of antigens prepared by disintegration of bacteria. Results: Levels of antibodies against P. gingivalis (OR = 1.48) and A. actinomycetemcomitans (1.31) associated with periodontitis, as determined by univariable logistic regression analysis. These antibody levels also associated with CVD (1.17 and 1.37), respectively, However, after adjusting for other risk factors, including age, smoking, gender, alcohol consumption, overweight, and level of education using multivariable logistic regression analysis, only increasing body mass index (BMI; 1.09), previous smoking (1.99), and increasing age (decades) (2.27) remained associated with CVD. Increased levels of antibodies agai...Continue Reading

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Citations

Sep 5, 2018·European Journal of Oral Sciences·Mogens Kilian
Aug 3, 2019·Journal of Clinical Medicine·Eija KönönenUlvi Kahraman Gursoy
May 10, 2020·Periodontology 2000·David HerreraBjorn Klinge
May 3, 2019·Mediators of Inflammation·Anilei HoareDenisse Bravo
Jul 28, 2021·Clinical Oral Investigations·Constanza JiménezMarcela Hernández
Sep 22, 2021·Journal of Clinical Periodontology·Chaitanya JoshiKarolin Hijazi
Nov 12, 2020·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Heidi Tuominen, Jaana Rautava

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

R
Genesis LITE
RStudio

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