Abstract
Outcomes may differ after kidney transplantation compared to combined liver-kidney transplantation. In animal models, distinct patterns of antidonor immunoglobulin (Ig) G subclasses are associated with either rejection or transplant tolerance. Flow cytometry has increased the sensitivity of antidonor immunoglobulin detection. We compared antidonor IgG subclass responses in kidney transplant recipients to those in recipients of liver or multiorgan grafts. In this study of 19 organ (kidney, liver, pancreas) transplantations, recipient serum incubated with donor splenocytes was tested by flow cytometry for the presence of IgM, IgG, or IgG subclass 1-4. Sera before transplantation and 10 days and 100 days after transplantation were used. No differences were seen in antidonor IgM, IgG, or IgG subclass antibodies among recipients of kidney transplants and liver grafts or combination grafts, either before or after transplantation. IgG4 gradually but significantly increased after transplantation in all groups. High levels of antidonor IgG3 either before transplantation or produced after it were found in 3 kidney recipients who experienced acute rejection. No other patients experienced rejection, and no other increase in IgG3 was seen. ...Continue Reading
References
Sep 24, 1966·Lancet·F Kissmeyer-NielsenO Fjeldborg
Oct 1, 1965·Annals of Surgery·T E StarzlW R Waddell
Aug 15, 1995·Transplantation·O FargesH Bismuth
Jan 1, 1994·Transplant Immunology·S L SaidmanJ J Fung
Aug 1, 1993·Transplantation·K OguraT Mackett
Mar 10, 1999·Transplantation·M KasaharaK Tanaka
Mar 19, 1999·Clinical Transplantation·M KotbA O Gaber
Apr 24, 1999·Journal of the American Society of Nephrology : JASN·Z GaoA I Lazarovits
Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M de MartinoA Vierucci
Nov 24, 1999·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M C JenmalmP G Holt
Jan 11, 2000·Transplantation·R H KermanB D Kahan
Feb 29, 2000·Clinical Transplantation·M Müller-SteinhardtH Klüter
May 26, 2001·Transplantation·J C ScornikR J Howard
May 26, 2001·Transplantation·A PiazzaC U Casciani
May 26, 2001·Transplantation·U P NeumannP Neuhaus
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Martin KarpinskiPeter Nickerson
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ronald P PelletierCharles G Orosz
Jul 9, 2002·Clinical Transplantation·Pam KimballMarc Posner
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Chloe C McAlisterKevork Peltekian
Citations
Apr 29, 2011·Transplantation·Manuel AriasManuel Praga
Jun 4, 2011·Transplantation·Gideon HöngerPatrizia Amico
Nov 28, 2007·Annual Review of Pathology·Lynn D CornellRobert B Colvin
Dec 17, 2014·Transplantation Reviews·C K BurghuberS J Knechtle
Jan 27, 2016·Digestive Diseases and Sciences·Viran GunasekeeraDevinder Kumar
Aug 13, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Natasha KhovanovaDavid Lowe
Nov 5, 2011·Seminars in Immunology·R Neal Smith, Robert B Colvin
Nov 21, 2007·Transplantation Proceedings·M BanasikM Klinger
Jun 14, 2006·Xenotransplantation·Byram W BridleBonnie A Mallard
Mar 27, 2007·Xenotransplantation·Joanne L Zahorsky-ReevesDonald V Cramer
Apr 18, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hugo KanekuGöran B Klintmalm
Oct 15, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Marie-Luise ArnoldAliki G Iniotaki
Nov 9, 2016·Frontiers in Immunology·Nicole M ValenzuelaElaine F Reed
Dec 22, 2017·Transplantation·Nicole M Valenzuela, Stefan Schaub
Aug 22, 2015·Journal of the American Society of Nephrology : JASN·Carmen LefaucheurAdriana Zeevi
Mar 16, 2007·Journal of the American Society of Nephrology : JASN·Robert B Colvin
Aug 8, 2008·Current Opinion in Organ Transplantation·Georg A BöhmigMarkus Wahrmann
May 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole M ValenzuelaElaine F Reed
Apr 29, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anat R TamburPeter Nickerson
Aug 7, 2019·Transplantation·Bong-Ha ShinMieko Toyoda
Apr 5, 2017·Journal of Immunology Research·Carrie L ButlerElaine F Reed