PMID: 2101121Jan 1, 1990Paper

Immunoglobulin G subclass deficiency in children with high levels of immunoglobulin E and infection proneness

International Archives of Allergy and Applied Immunology
R K LohA Ferrante

Abstract

Of 32 unrelated children with serum IgE greater than 1,000 U/ml, 17 were found to have infection proneness according to standard clinical criteria, and 15 were not infection prone. There were no statistical differences between these 2 groups of children with regard to age, sex, serum IgE levels or prevalence of asthma. However, the prevalence of eczema was significantly lower in the infection-prone group (p = 0.035). Of greater interest was the finding that 7 children in the infection-prone group had IgG subclass and/or IgA deficiency compared with none in the non-infection-prone group (p = 0.006). These results suggest that IgG subclass studies may be warranted in children with markedly elevated levels of serum IgE and proneness to infection.

Citations

Feb 9, 1999·The Journal of Allergy and Clinical Immunology·O GarraudT B Nutman
Feb 23, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Kelley L Colvin, Michael E Yeager
Feb 24, 2001·Pediatrics International : Official Journal of the Japan Pediatric Society·H CaksenA Uner

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