PMID: 9160087May 1, 1997Paper

Immunoglobulin gene organization and the mechanism of repertoire development

Scandinavian Journal of Immunology
J E Butler

Abstract

Recombinant DNA technology has made it possible to comparatively examine the immunoglobulin (Ig) gene constitution of numerous species. These studies reveal that many species diverge from the pattern seen in rodents and primates while revealing a number of interesting correlations involving Ig gene organization, B-cell lymphogenesis and the mechanism of repertoire development; many of these fail to correlate with traditional phylogenetic relationships. These correlates pose new questions regarding repertoire developments, which suggest that considerable diversity exists in the process. These findings also allow new questions to emerge regarding the role of IgD, the size of the B-cell repertoire, and the role that antigen may or may not play in repertoire development. These issues are discussed with the intention of stimulating experimentation to test a number of speculative hypotheses regarding B-cell and repertoire development.

Citations

Oct 6, 2007·Immunologic Research·J E Butler, Marek Sinkora
Aug 3, 2001·Molecular Immunology·B B HainesP H Brodeur
Mar 14, 2000·Veterinary Immunology and Immunopathology·P NavarroJ E Butler
Dec 30, 1999·Veterinary Immunology and Immunopathology·R AitkenR MacDuff
Sep 13, 2003·Fish & Shellfish Immunology·Sigrun Espelid, Randi Nygaard Grøntvedt
Jun 27, 2013·Animal Health Research Reviews·Randall L Levings, James A Roth
Jan 20, 2010·Immunology and Cell Biology·Noorjahan Banu AlitheenPeter McCullagh
Aug 14, 1999·Scandinavian Journal of Immunology·I HordvikB Krossøy
Oct 12, 2010·Clinical and Vaccine Immunology : CVI·L P Daley-BauerJ A Appleton
Jul 5, 2012·PloS One·Yongchen GuoYaofeng Zhao
Dec 3, 2008·Immunogenetics·J E ButlerImre Kacskovics
Sep 20, 2005·Biochemical and Biophysical Research Communications·Gertrudis RojasJorge V Gavilondo
Jul 13, 2007·Developmental and Comparative Immunology·Tong QinYaofeng Zhao
Sep 8, 2005·Veterinary Immunology and Immunopathology·Marek SinkoraJana Sinkorova
Aug 24, 2017·PloS One·Dennis K LanningKatherine L Knight
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeannette JohanssonLars Hellman
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle L BakerRobert D Miller
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J E ButlerR K Christenson
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E ButlerKevin Wells
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E Butler, Nancy Wertz
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yaofeng ZhaoLennart Hammarstrom
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·John E ButlerDavid Francis
Aug 2, 2005·Developmental and Comparative Immunology·Yaofeng ZhaoRobert Aitken

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