Immunoglobulin heavy-chain receptor editing is observed in the NOD/SCID model of human B-cell development

Scandinavian Journal of Immunology
G R Kolar, J D Capra

Abstract

Receptor editing and receptor revision are the two mechanisms of antibody diversity that result in either complete V-gene replacement or the formation of hybrid V genes. We do not yet understand how this process unfolds, because they are rare and difficult to study in vivo. In this study, we describe a family of VH4-34:VH4-61 hybrids isolated from a human B-cell chimeric non-obese diabetic/severe combined immunodeficient mouse. The observation of hybrid immunoglobulin sequences in human B cells that developed in this model system makes it useful for the study of this mechanism of diversification and tolerance.

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Citations

Jan 26, 2005·Immunology·John M Darlow, David I Stott
Mar 15, 2006·The Journal of Biological Chemistry·Negar S RahmanKarla K Rodgers
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy S LongoPeter E Lipsky

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