Immunoglobulin-induced aseptic meningitis: a case report

BMC Neurology
Luísa GraçaAntónio Sarmento

Abstract

Immunoglobulin associated meningitis is a rare disease that mimics infectious meningitis. This is, to our knowledge, the first case of Immunoglobulin-associated meningitis described in a patient with Systemic Lupus Erythematosus and hypogammaglobulinemia secondary to Rituximab. A 46-year-old female with a past medical history of Systemic Lupus Erythematosus, presented with meningismus 36 h after first infusion of intravenous immunoglobulin. The cerebrospinal fluid analysis showed neutrophilic pleocytosis and hyperproteinorrachia. All microbiological tests were negative. The patient recovered remarkably fast without sequela after just five days of antibiotic therapy. Systemic Lupus Erythematosus is a well-documented risk factor for aseptic meningitis associated with other drugs. Possibly, it is also a risk factor for Immunoglobulin associated meningitis. This diagnosis, although rare, should be considered in patients receiving Immunoglobulin since it is a self-limited condition and treatment is supportive.

References

Jun 17, 1999·Archives of Internal Medicine·G Moris, J C Garcia-Monco
Jan 25, 2011·Journal of Clinical Pharmacology·A ChaabaneS Mahjoub
Jul 9, 2014·JAMA Internal Medicine·German Morís, Juan Carlos Garcia-Monco
May 20, 2015·Oxford Medical Case Reports·Rajendra Singh JainJagdeesh Chandra Kookna

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Citations

Apr 26, 2019·Current Opinion in Infectious Diseases·Arun Venkatesan

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Methods Mentioned

BETA
Nucleic Acid Amplification

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