PMID: 2501791Jul 1, 1989Paper

Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein

Proceedings of the National Academy of Sciences of the United States of America
G F HollisJ P McKearn

Abstract

Human pre-B cells, which produce immunoglobulin heavy chain but do not produce immunoglobulin light chain, are shown to contain a 1-kilobase transcript homologous to immunoglobulin lambda light-chain genes. Detailed analysis of RNA and cDNA clones derived from these transcripts reveals that they originate from the distinct immunoglobulin lambda-like genes 14.1/16.1. Sequence analysis of these clones reveals a long open reading frame, beginning with an ATG, capable of encoding a protein of 214 amino acids with an unprocessed molecular weight of 22,944. The C-terminal half of this predicted protein is highly homologous to immunoglobulin lambda light-chain joining and constant region protein sequence, while the amino-terminal end does not share homology with variable regions. Unlike immunoglobulin genes, these genes do not undergo rearrangement prior to expression. Analysis of a panel of 26 hematopoietic cell lines reveals that expression of 14.1/16.1 is limited to pre-B cells and one B-cell line, which, like the pre-B cells, is surface immunoglobulin negative. Antisera raised against a peptide whose sequence was predicted from the 14.1 cDNA sequence identifies a 22-kDa protein in human pre-B cells. Immunoprecipitation of immunogl...Continue Reading

References

Aug 1, 1986·The Journal of Experimental Medicine·U StorbR L Brinster
Feb 1, 1986·The Journal of Experimental Medicine·H ChangG F Hollis
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P DariavachM P Lefranc
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S J KorsmeyerP Leder
Apr 14, 1983·Nature·S Tonegawa
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Sep 19, 1980·Science·R MakiS Tonegawa
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R P PerryJ F Kearney

❮ Previous
Next ❯

Citations

Apr 1, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J van Dongen, I L Wolvers-Tettero
Feb 1, 1993·Immunology Today·F MelchersA Rolink
Apr 1, 1991·Current Opinion in Immunology·T Tsubata, S Nishikawa
Feb 5, 2000·Experimental Hematology·T TaguchiJ Fujimoto
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N NishimotoM D Cooper
Jul 1, 1990·The Journal of Experimental Medicine·J G VillablancaT W LeBien
Aug 1, 1990·The Journal of Experimental Medicine·T J Vasicek, P Leder
Oct 1, 1990·The Journal of Experimental Medicine·T OhnoM D Cooper
Feb 1, 1996·The Journal of Experimental Medicine·K LassouedM D Cooper
Apr 1, 1993·Immunological Reviews·J BorstJ J van Dongen
Apr 28, 2010·FEBS Letters·Inga-Lill MårtenssonAngelina I Bernardi
Aug 12, 2016·Scientific Reports·Lucyna BudzkoMarek Figlerowicz
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nobutaka KiyokawaJunichiro Fujimoto
Jan 1, 1992·International Reviews of Immunology·C SchiffM Fougereau
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M E DonohoeB B Blomberg
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T FangC A Roman
Sep 29, 1995·Annals of the New York Academy of Sciences·L G BillipsM D Cooper
Dec 1, 2018·Frontiers in Immunology·Thomas H Winkler, Inga-Lill Mårtensson
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SatoA Kudo
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ramiro Gisler, Mikael Sigvardsson
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hiromu SatoAkira Kudo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.