Feb 14, 1970

Immunoglobulin levels in the cerebrospinal fluid

British Medical Journal
D Riddoch, R A Thompson


The immunoglobulins G, A, M, and D have been measured in the cerebrospinal fluid of 207 patients with neurological disease. Raised levels of IgG, expressed as a percentage of total cerebrospinal fluid (C.S.F.) protein, were found in 62% of 45 cases of multiple sclerosis compared with 14% of 160 cases with various other neurological disorders. Thus measurement of the IgG level is probably a useful confirmatory investigation in multiple sclerosis. IgA and IgM were found only in the C.S.F. of patients with a raised protein level, and IgD was not detected.

Mentioned in this Paper

Immunoglobulin Activity
Cerebrospinal Fluid
Gamma globulin
MS gene
Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis
Immunoglobulin Measurement

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