Feb 14, 1970

Immunoglobulin levels in the cerebrospinal fluid

British Medical Journal
D Riddoch, R A Thompson

Abstract

The immunoglobulins G, A, M, and D have been measured in the cerebrospinal fluid of 207 patients with neurological disease. Raised levels of IgG, expressed as a percentage of total cerebrospinal fluid (C.S.F.) protein, were found in 62% of 45 cases of multiple sclerosis compared with 14% of 160 cases with various other neurological disorders. Thus measurement of the IgG level is probably a useful confirmatory investigation in multiple sclerosis. IgA and IgM were found only in the C.S.F. of patients with a raised protein level, and IgD was not detected.

Mentioned in this Paper

Immunoglobulin Activity
Cerebrospinal Fluid
IgG2B
Immunoglobulins
IgM2
Gamma globulin
MS gene
Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis
Immunoglobulin Measurement

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