Mar 2, 2005

Immunoglobulin locus silencing and allelic exclusion

Seminars in Immunology
Anne E Corcoran

Abstract

Lymphocytes are characterised by monoclonal expression of antigen receptors. This is achieved by silencing of one of two homologous antigen receptor alleles, a process known as allelic exclusion. This process is regulated both before and after V(D)J recombination, by a variety of mechanisms. These include nuclear localisation, changes in chromatin structure and histone modifications, non-coding sense and antisense RNA transcription, epigenetic alterations at the DNA level, feedback signalling from expressed alleles, locus contraction and decontraction, recruitment to heterochromatin. This review will focus on recent advances in the immunoglobulin heavy and kappa light chain loci. The current picture is of a complex, temporally ordered sequence of events, in which these loci share many contributory mechanisms, but clear and intriguing differences are emerging.

  • References66
  • Citations28

References

  • References66
  • Citations28

Citations

Mentioned in this Paper

Establishment and Maintenance of Localization
DNA Methylation [PE]
Covalent Interaction
Nucleosomes
RAG1 gene
Histone antigen
T-Lymphocyte
CFC1 gene
Deoxyribonuclease I
IL7R gene

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