PMID: 6408962Jul 1, 1983Paper

Immunoglobulin M and G histoplasmal antibody response in histoplasmosis

The American Review of Respiratory Disease
L J WheatZ Brahmi

Abstract

Radioimmunoassays for IgM and IgG histoplasmal antibodies were developed and proved to be specific for their respective immunoglobulin classes, sensitive, and reproducible. Elevated IgM antibodies were detected in 59.8% of patients with histoplasmosis and 7.9% of control subjects. Elevated IgG antibodies occurred in 80.4% of patients with histoplasmosis but in only 12.9% of control subjects. Radioimmunoassay was nearly twice as sensitive as complement fixation for identifying patients with mild, presumably asymptomatic, infection. Of 13 patients with serologic follow-up at least 1 yr later, elevated IgM antibodies cleared, whereas IgG antibodies persisted in 7. In an epidemiologic investigation of a recurrent histoplasmosis outbreak, only the radioimmunoassay was able to prove the hypothesis that construction for a swimming complex was the source of exposure. These assays promise to be useful for clinical and epidemiologic investigations.

Citations

Jan 23, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah M RicherL Joseph Wheat
Jan 1, 1990·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·A J HamiltonR J Hay
Feb 1, 1985·The American Journal of Medicine·L J WheatM L Zeckel
Mar 10, 2017·Journal of Clinical Microbiology·Marwan M Azar, Chadi A Hage
Aug 18, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L J Wheat
Nov 24, 1999·Allergy·E Millqvist
Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·L de Repentigny
Oct 20, 2006·Expert Opinion on Biological Therapy·L Joseph Wheat
Dec 23, 1999·The Pediatric Infectious Disease Journal·C M OdioA Carranza
Jun 9, 2020·Biocontrol Science·Haruna SasakiHiroshi Morita
Aug 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J H PersoonsG Kraal
Jan 16, 2007·Clinical Microbiology Reviews·Carol A Kauffman
Jan 2, 2021·Journal of Fungi·Kathleen A Linder, Carol A Kauffman
Nov 1, 1993·Infection and Immunity·M F FojtasekC T Schnizlein-Bick
Mar 1, 1986·Journal of Clinical Microbiology·J WheatR P Tewari
Oct 15, 2003·Trends in Microbiology·L Joseph Wheat

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