PMID: 2507746Aug 1, 1989Paper

Immunoglobulin M in the cerebrospinal fluid: an indicator of recent immunological stimulation

Journal of Neurology, Neurosurgery, and Psychiatry
M K Sharief, E J Thompson

Abstract

Using a sensitive new method for detecting oligoclonal immunoglobulin M (IgM) in unconcentrated cerebrospinal fluid (CSF), the intrathecal synthesis of IgM was correlated with that of free light chains in patients with multiple sclerosis, infections of the central nervous system and other neurological conditions. A strong correlation was found between the presence of oligoclonal IgM and that of free light chains in the CSF from patients with multiple sclerosis and infections of the central nervous system. No oligoclonal IgM response was observed in patients with non-inflammatory or non-infectious neurological conditions. This implies that oligoclonal IgM has the same diagnostic significance as free light chains.

References

Mar 1, 1978·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·F BollengierA Lowenthal
Jul 1, 1986·Annals of Neurology·R A RudickR M Herndon
Jun 1, 1987·Journal of Neurology·F BraccoB Tavolato
Oct 1, 1985·Neurology·R A RudickD W Knutson
Oct 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·A Vakaet, E J Thompson
Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·E J Thompson, G Keir
Jan 1, 1983·Annals of Neurology·J R MillerC T Bever

❮ Previous
Next ❯

Citations

Jul 16, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·R Kaiser, C H Lücking
Apr 1, 1996·Journal of Biochemical and Biophysical Methods·P F Zatta
May 1, 1993·Journal of Neuroimmunology·G MartinoL M Grimaldi
Apr 25, 1997·Journal of Immunological Methods·C A RijckenA W Teelken
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M K Sharief
Sep 12, 1991·The New England Journal of Medicine·M K ShariefM Ciardi
Jul 31, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R SchneiderS Rauer
Nov 1, 1991·Acta Neurologica Scandinavica·M K Sharief
Oct 24, 1998·Acta Neurologica Scandinavica·M KrakauerF Sellebjerg
Feb 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·M K Sharief, E J Thompson
Apr 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·A StevensH Wiethölter
Jan 6, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E Alvarez
Jan 11, 2019·The American Journal of Tropical Medicine and Hygiene·Aung Kyaw KyawKouichi Morita
Feb 25, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Mattia FondericoMaria Pia Amato
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory P OwensDonald H Gilden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.