PMID: 6988938Jan 1, 1980Paper

Immunoglobulin-producing cells in jejunal mucosa of children with coeliac disease on a gluten-free diet and after gluten challenge

Scandinavian Journal of Gastroenterology
H ScottP Brandtzaeg

Abstract

The jejunal Ig-producing cell populations in a group of 12 children with established coeliac disease (CD) in remission on a gluten-free diet were compared with those of a group of 10 patients in clinical relapse after gluten challenge. Quantification of the various immunocyte classes was performed by paired immunofluorescence staining in an individually defined mucosal tissue unit constituting a 6-micron-thick and 500-micron-wide block of tissue, including the mucosa at full height from the muscularis mucosae. In the treated group the percentage IgA/IgM/IgG cell ratios were, on the average, 82.6:12.9:4.5. There were no differences in these ratios or in the absolute immunocyte numbers when compared with a group of six control patients without CD. After gluten challenge the corresponding ratios were 77.2:17.2:5.6. The median cell number per mucosal tissue unit in the IgA, IgM, and IgG class was raised 2.1, 3.8 and 2.9 times, respectively. These increases were statistically significant. Moreover, there was a significant negative correlation between the time to clinical relapse and the number of IgG cells per tissue unit after challenge. This finding indicates that locally produced antibodies of the IgG class are especially involve...Continue Reading

References

Jan 1, 1978·Irish Journal of Medical Science·F M StevensC F McCarthy
Jun 1, 1974·Archives of Disease in Childhood·H J Cornell
Jul 1, 1980·Archives of Disease in Childhood·B McNichollP F Fottrell
Mar 1, 1965·The Journal of Clinical Investigation·W RUBING H JEFRIES

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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·H ScottP Brandtzaeg
Jan 1, 1992·Digestive Diseases and Sciences·B LavöR Hällgren
Feb 27, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·A G Davidson, M A Bridges
Jan 1, 1996·APMIS. Supplementum·S U Friis
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·P C RosekransC J Meijer
Nov 26, 2015·Seminars in Immunology·J Stamnaes, L M Sollid
May 2, 2006·Immunology Letters·Per Brandtzaeg
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P BrandtzaegK Baklien
Dec 17, 2019·United European Gastroenterology Journal·Omri SnirLudvig M Sollid

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