PMID: 2494658Mar 1, 1989Paper

Immunoglobulin receptor signaling depends on the carboxyl terminus but not the heavy-chain class

Proceedings of the National Academy of Sciences of the United States of America
C F WebbP W Tucker

Abstract

To examine the isotypic and structural requirements involved in signaling through the immunoglobulin (Ig) receptor on B lymphocytes, we established a panel of T15 idiotype-positive transfectants that expressed wild-type IgM, wild-type IgD, or hybrid IgM molecules. Growth inhibition of the transfected lymphoma cells in response to anti-idiotype antibodies was used to measure signaling. Hybrid IgM molecules were constructed so that the membrane-spanning region of the mu heavy chain was replaced by that of delta, gamma 2b, or alpha heavy chains or that of the I-Ab class II (Ia) alpha chain. All transfectants that expressed IgM or hybrid IgM molecules with membrane-spanning regions from another Ig isotype underwent signaling in response to anti-idiotype antibodies, whereas the IgM-Ia hybrid transfectants did not. Transfectants that expressed wild-type IgD molecules also underwent signaling, although this response was particularly sensitive to serum concentrations. These results imply that signaling occurs in a similar manner through heavy-chain receptors of any isotype and suggest that conserved amino acid sequences in the transmembrane regions are important in this process.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 19, 1975·Science·E S Vitetta, J W Uhr
Jan 1, 1987·Annual Review of Immunology·J C Cambier, J T Ransom
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C A PennellG Haughton
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R TischN Hozumi
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J E Alés-MartínezD W Scott
Feb 2, 1984·Nature·F R Blattner, P W Tucker
Jan 1, 1980·Immunological Reviews·E VitettaJ Uhr

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Citations

Oct 1, 1992·The Journal of Experimental Medicine·V S ParikhP W Tucker
Apr 1, 1993·Immunological Reviews·E BaixerasC Martínez
Sep 7, 1995·Annals of the New York Academy of Sciences·A L DeFrancoM R Gold

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