Immunoglobulin Replacement Therapy Versus Antibiotic Prophylaxis as Treatment for Incomplete Primary Antibody Deficiency.

Journal of Clinical Immunology
Bas M SmitsJoris M van Montfrans

Abstract

Patients with an IgG subclass deficiency (IgSD) ± specific polysaccharide antibody deficiency (SPAD) often present with recurrent infections. Previous retrospective studies have shown that prophylactic antibiotics (PA) and immunoglobulin replacement therapy (IRT) can both be effective in preventing these infections; however, this has not been confirmed in a prospective study. To compare the efficacy of PA and IRT in a randomized crossover trial. A total of 64 patients (55 adults and 9 children) were randomized (2:2) between two treatment arms. Treatment arm A began with 12 months of PA, and treatment arm B began with 12 months of IRT. After a 3-month bridging period with cotrimoxazole, the treatment was switched to 12 months of IRT and PA, respectively. The efficacy (measured by the incidence of infections) and proportion of related adverse events in the two arms were compared. The overall efficacy of the two regimens did not differ (p = 0.58, two-sided Wilcoxon signed-rank test). A smaller proportion of patients suffered a related adverse event while using PA (26.8% vs. 60.3%, p < 0.0003, chi-squared test). Patients with persistent infections while using PA suffered fewer infections per year after switching to IRT (2.63 vs. 0....Continue Reading

References

Jan 1, 1991·The Journal of Allergy and Clinical Immunology·D P HustonM M Huston
Aug 1, 1991·Clinical and Experimental Immunology·E Bernatowska-MatuszkiewiczM M Eibl
Aug 1, 1993·The Journal of Allergy and Clinical Immunology·I B BarlanL C Schneider
Jan 1, 1993·Allergy Proceedings : the Official Journal of Regional and State Allergy Societies·A GandhiM Ballow
Jun 14, 2002·The Journal of Allergy and Clinical Immunology·Paula Jane BusseCharlotte Cunningham-Rundles
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove, Yehuda Carmeli
May 12, 2004·International Immunopharmacology·Javier de GraciaFerran Morell
Mar 17, 2007·Scandinavian Journal of Infectious Diseases·Ann-Margreth Olinder-NielsenJanne Björkander
Jan 25, 2008·Journal of Clinical Immunology·Isabella QuintiMassimo Fiorilli
Jul 8, 2008·The Journal of Allergy and Clinical Immunology·Vincent R BonaguraDavid W Rosenthal
Feb 17, 2009·International Archives of Allergy and Immunology·Nabih I AbdouJohn F Halsey
Oct 22, 2009·Clinical and Experimental Immunology·C Cunningham-Rundles
Oct 23, 2012·Frontiers in Immunology·Denise A KaminskiIgnacio Sanz
Apr 2, 2013·The Journal of Allergy and Clinical Immunology·Erwin W GelfandWilliam T Shearer
May 10, 2013·Journal of Clinical Immunology·Ahmed Aziz BousfihaJean-Laurent Casanova
Oct 16, 2013·Current Opinion in Allergy and Clinical Immunology·Helen Chapel, Ann Gardulf
Sep 27, 2014·Journal of Clinical Immunology·Lisa KobrynskiScott Bowen
Jan 27, 2015·The Lancet Infectious Diseases·James A ChurchAndrew J Prendergast
Aug 21, 2015·Expert Review of Clinical Immunology·Payam MohammadinejadAsghar Aghamohammadi
Apr 16, 2016·The American Journal of the Medical Sciences·Marie T BrownSuja Mathew
Nov 20, 2016·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Lusine AbrahamyanSamir Gupta
Dec 22, 2016·Clinical and Experimental Immunology·S JollesJ Litzman
Jan 4, 2017·The Journal of Allergy and Clinical Immunology·Elena E PerezMark Ballow
Jun 29, 2018·Frontiers in Immunology·Yi GuoZheng Xiao
Mar 27, 2019·The Journal of Allergy and Clinical Immunology·Cinzia MilitoIsabella Quinti
May 28, 2019·The Cochrane Database of Systematic Reviews·Christopher Jd ThreapletonEmma H Baker
Aug 1, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Amrita Khokar, Sudhir Gupta
Nov 5, 2019·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M H KoenenL M Verhagen
Nov 24, 2019·Journal of Clinical Immunology· Joud HajjarKathleen E Sullivan
Feb 13, 2020·Journal of Clinical Immunology·Aziz BousfihaStuart G Tangye

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