Immunoglobulin-specific T-B cell interaction. I. Presentation of self immunoglobulin determinants by B lymphocytes.

European Journal of Immunology
A Rudensky, V L Yurin

Abstract

Immunoglobulin (Ig)-specific T-B cell interactions have been studied in the model of T cell recognition of the kappa chain Ig kappa-1b allotype in Ig kappa-1-congeneic rat strains. An efficient presentation of endogenous Ig allotypic determinants by irradiated spleen cells from (WAG.1b x August)F1 (RT-1u/c; Ig kappa-1b/1a) rats to Ig kappa-1b-specific lymph node T cells from Ig kappa-1-congeneic (WAG x August)F1 (RT-1u/c; Ig kappa-1a) rats was demonstrated. This presentation was found to be sensitive to high irradiation doses (greater than 1000 rad). By fractionation of Ig kappa-1b+ F1 spleen cells on Percoll density gradient we have shown that a radioresistant, low-density fraction, consisting mainly of macrophages (M phi) and dendritic cells, triggers only weak Ig kappa-1b-specific T cell response. The high level of response was observed against radiosensitive spleen cell fractions of intermediate and high density, suggesting that B cells were the main antigen-presenting cells (APC) of Ig kappa-1b determinants of endogenous Ig. This conclusion was confirmed in the experiments using purified B cells from Ig kappa-1b-bearing rats. Earlier we have shown that the responsiveness of August (RT-1c; Ig kappa-1a) and WAG (RT-1u; Ig ka...Continue Reading

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Citations

Jan 1, 1996·The Journal of Experimental Medicine·F GranucciP Ricciardi-Castagnoli
Jul 1, 2004·The Journal of Experimental Medicine·Christopher M SnyderLawrence J Wysocki
Dec 20, 2012·Autoimmunity·Thiago DetanicoLawrence J Wysocki
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Apr 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Prashant Nair, Jan Vilcek
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A ChoudhuryV Bal
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher M SnyderLawrence J Wysocki
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Nov 28, 2000·European Journal of Immunology·L MajlessiG Bordenave

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