Immunoglobulin-specific T-B cell interaction. II. T cell clones recognize the processed form of B cells' own surface immunoglobulin in the context of the major histocompatibility complex class II molecule

European Journal of Immunology
V L YurinJ M Blechman

Abstract

In the preceding report (Eur. J. Immunol. 1989. 19: 1677) we have demonstrated that normal B cells, including small B cells, are capable of presenting Ig kappa-1b allotypic determinants of their endogeneously synthesized Ig+ to Ig kappa-1b-immune major histocompatibility complex (MHC) class II-restricted T cells. A panel of Ig kappa-1b allotype-specific T cell clones from August rats has been developed to study further the presentation of self surface Ig by B cells from Ig kappa-1-congeneic August.1b rats. All the clones studied were of the T helper/inducer phenotype (W3/25+,OX8-) and restricted by the RT-1Bc molecule. These clones responded both to the serum IgG(Ig kappa-1b) in the presence of irradiated spleen cells (SC) from August rats and to the Ig kappa-1b-bearing irradiated B cells from August.1b rats. SC presentation of secreted IgG was much less effective than B cell presentation of membrane Ig. Using CNBr cleavage of isolated C kappa (Ig kappa-1b) domain followed by high-performance liquid chromatography fractionation of the derived antigenic peptides, the kappa chain sequence between amino acids 176 and 214 has been identified as the T cell epitope recognized by all T cell clones in association with RT-1Bc. The fragm...Continue Reading

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Citations

Feb 1, 1992·Current Opinion in Immunology·E R Unanue
Jul 1, 2004·The Journal of Experimental Medicine·Christopher M SnyderLawrence J Wysocki
Sep 16, 2000·Current Opinion in Rheumatology·R R Singh
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Nov 21, 2014·European Journal of Haematology·Maria Antonia FrassanitoAngelo Vacca
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ram Raj SinghBevra H Hahn
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elin LundeBjarne Bogen

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